多项肿瘤标志物联合检测早期诊断原发性肝癌的研究

Combined five tumor markers in detecting primary hepatic carcinoma

目的 探讨提高原发性肝癌 (PHC)的检出率 ,早期诊断原发性肝癌的方法。 方法 对 5 0例PHC患者 ,30例肝外恶性肿瘤 (NHC)患者及 30例肝硬化 (LC)患者以甲胎蛋白 (AFP)的检测为主体 ,配合谷氨酰转肽酶 (γ GT)、α L 岩藻糖苷酶 (AFU)、肿瘤坏死因子 (TNF α)和DR 70 TM检测 ,比较优化组合 ,联合检测的结果。 结果 AFP阴性的PHC患者中 ,AFU、γ GT、TNF α和DR 70 TM5项指标联合检测的阳性率为 99 4% ,再包括AFP阳性的PHC患者 ,则AFP、AFU、γ GT、TNF α和DR 70 TM5项指标的阳性率可达 98% ,与AFP单项 (6 4 0 % )检测阳性率比较差异有非常显著性意义 (P <0 0 1)。 结论 应用AFP、AFU、γ GT、TNF α和DR 70 TM5项肿瘤标志物联合检测PHC可大大提高阳性率 ,其中首选AFP与DR 70 TM组合 ,其次为AFP与AFU组合。有利于PHC的早期诊断 ,也有利于PHC与肝硬化 (LC)的鉴别诊断。

Objective[WT5”BZ] To increase the detection rate of primary hepatic carcinoma (PHC) and to diagnose PHC earlier. [WT5”HZ]Methods[WT5”BZ] AFP was combined with r glutamyle transpeptidase (r GT), α fucosidase (AFU), tumor necrosis factor α (TNF α) and DR 70 TM . [WT5”HZ]Results[WT5”BZ] The positive detection rate of PHC negative AFP with combined four markers was 9 4%. The total positive detection rate of PHC with combined five tumor markers reached 98 0% which was significantly higher than that with AFP ( P <0 01). [WT5”HZ]Conclusions[WT5”BZ] The positive detection rate of PHC can be increased by combined five tumor markers. It is helpful in diagnosing PHC earlier and can differentiate PHC from liver cirrhosis. [WT5”HZ]