上海闵行地区胆固醇结石病易患因素分析

Risk factors of cholesterol gallstone disease among the patients in Minhang district of Shanghai

目的 研究上海郊县闵行地区胆固醇结石病人载脂蛋白 (Apo)B基因XbaⅠ多态性 ,以及血脂、胆囊收缩功能的改变 ,探讨胆石病危险因素。方法 对 3 4例胆囊结石患者和 10 1例正常人 ,采用PCR RFLP方法测定ApoB基因XbaⅠ多态性、检测血脂和胆囊壁厚、胆囊空腹容积、残余容积、排空率的改变。结果 胆石组ApoB基因X + /-基因型 (2 3 .5 3 % )和X +等位基因 (11.76% )显著高于对照组(7.92 % ,3 .96% )。胆石组和对照组血脂差异无显著性 (P >0 .0 5 )。胆石组胆囊空腹容积、餐后残余容积大于对照组 ,而排空率减小。结论 携带X +等位基因、胆囊壁厚增加和胆囊收缩功能减弱是胆固醇结石病的易患因素。

Objective\ To study the apolipoprotein (Apo) B gene Xba I polymorphism, serum lipids and contractility of gallbladder in the patients with cholesterol gallstone disease (CGD) and investigate the risk factors for CGD. Methods\ Genotypes of Xba I polymorphism, serum lipids, wall thickness of gallbladder, fasting volume, residual volume, and ejection fraction were measured among the 34 patients with gallbladder stone and 101 control subjects. Results\ Frequencies of X+/- genotype (23.53 %) and X+ allele (11.76 %) were significantly higher in the CGD patients than in control group (7.92 %, 3.96 %). There was no significant difference in serum lipids between the two groups. The CGD patients had a significantly increased wall thickness of gallbladder with enlarged fasting volume, residual volume and decreased ejecting fraction as compared with control group. Conclusion\ Conclusion X+allele of apo B gene, increased wall thickness of gallbladder and decreased contractility of gallbladder may be risk factors for CGD.