期刊文献+

胆固醇结石与载脂蛋白B基因多态性的关系 被引量:6

Relationship between polymorphisms of the apolipoprotein B gene and cholesterol gallstone disease
原文传递
导出
摘要 目的 探讨胆固醇结石病与载脂蛋白 (Apo)B基因多态性的关系。 方法 选择载脂蛋白B基因多态位点XbaⅠ、EcoRⅠ应用聚合酶链反应和限制性片段长度多态性 (PCR RFLP)技术对 10 1例胆固醇结石病人和 5 0例对照者进行研究。结果 胆固醇结石组X+等位基因频率显著高于对照组 (P<0 .0 5 ) ,具有X+等位基因者其血脂总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL c)及ApoB水平显著高于非X+者 (P <0 .0 1) ;胆固醇结石组和对照组在EcoRⅠ等位基因频率和血脂水平方面差异均无显著性 (P >0 .0 5 )。结论 X+等位基因可能是胆固醇结石的易感基因。 Objective\ To investigate the relationship between the apolipoprotein (Apo)B gene polymorphic sites Xbal, EcoRI and cholesterol gallstone disease. Methods Two polymorphic sites Xbal, EcoRI of ApoB gene were selected. Using polymerase chain reaction and restriction fragment length polymorphism technique 101 patients with cholesterol gallstone and 50 controls were investigated. Results The frequency of rare allele X + was significantly higher in the patients with cholesterol gallstone than in the controls. Patients with X+ allele had higher TC, LDL-c and ApoB levels, significantly different from those without X+ allele. There were no difference between the patient group and the control one in EcoRI allele. Conclusion X+ allele might be the susceptible gene for cholesterol gallstone disease.
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2000年第1期26-27,共2页 Chinese Journal of Experimental Surgery
基金 上海市科技发展基金!( 95 41190 2 7)
关键词 载脂蛋白B 胆固醇结石 基因多态性 Apolipoprotein B Gene Cholelithiasis Polymorphism
  • 相关文献

参考文献1

共引文献11

同被引文献65

  • 1吴瑞芳.对海勤人员泌尿系结石病的调查报告分析[J].世界最新医学信息文摘,2019,0(102):277-278. 被引量:1
  • 2宫轲 傅贤波 等.血清脂质、载脂蛋白与胆汁类脂相关性研究[J].中华外科杂志,1999,37:335-335.
  • 3Kraemer R, Pomerantz KB, Kesav S, et al. Cholesterol enrichment enhances expression of sterol carrier protein 2: implications for its function in intracellular cholesterol traffickong[J]. J Lipid Res, 1995 Dec, 36(12):2 630
  • 4David QH, Paigen B, Carey MC, et al. Phenotypic characterize of lith gene that determine susceptibility to cholesterol cholelithiasis in inbred mice:physical - chenmistry of gallbladder bike[J] .J Lipid Res, 1997,38:1 395
  • 5Fuchs M, Lammert F, Wang DQ, et al. Sterol carrier protein 2 participates in hypersecretion of biliary cholesterol during gallstone formation in genetically gallstone - susceptible mice[ J]. Biochem J, 1998,336(Pt 1 ): 33
  • 6Wang DH, Mizukami T, Okanura Y, et al. Sterol carrier protein 2 (SCP2)but not phosphatidylcholine transfer protein(Pctp) gene expression is enhanced during cholesterol gallstone formation in mice[ J]. Gastroenterology, 1997,112(4) :Al 267
  • 7Wirtz KW. Phospholipid transfer proteins revisited [ J]. Biochem J, 1997Jun 1,324(Pt 2) :353
  • 8Andrew K Diehl. Clinical correlates of gallstone composition: distinguishing pigment from cholesterol stones[J]. Cand Gastroenterology, 1996 Vol,31 (3) :273
  • 9庄小强.血脂与胆囊结石关系的探讨[J].新消化病学杂志,1995,3:176-176.
  • 10Eric J. Murphy.Sterol carrier protein‐2:Not just for cholesterol any more[J]. Molecular and Cellular Biochemistry . 2002 (1-2)

引证文献6

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部