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穿透性角膜移植术后环胞霉素A与皮质类固醇的合理应用 被引量:11

Topical application of cyclosporin A and corticosteroid in penetrating keratoplasty
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摘要 对穿透性角膜移植术后患者合理应用环胞霉素A滴眼液代替地塞米松滴眼液的疗效和眼压进行评价。方法:420例穿透性角膜移植术后患者,随机分成两组。A组:0.5%地塞米松滴眼液联合1%环胞霉素A滴眼液,每天4次,共3个月。B组:0.5%地塞米松滴眼液联合1%环胞霉素A滴眼液,每天4次,共1个月,后改用1%环胞霉素A滴眼液至3个月。对两组眼压和免疫排斥情况进行观察。结果:A组58例患者眼压>22mmHg,占25%;B组9例眼压>22mmHg,占5%。两组眼压统计(P<0.001),有非常显著性差异。停用0.5%地塞米松滴眼液后,1~2周大部分患者眼压降至正常。两组免疫排斥反应率无差异。 To evaluate the effects of cyclosporin A eye drop substituting dexamethasone eye drop properly to prevent allograft rejection after penetrating keratoplasty.Methods:420 cases of penetrating keratoplasty were divided into 2 groups.In group A, 0 5% dexamethasone eye drop combining with 1% cyclosporin A eye drop were given 4 times daily for 3 months.In group B,0 5% dexamethasone eye drop combining with 1% cyclosporin A eye drop were given 4 times daily for 1 month,and then 1% cyclosporin A eye drop was applied alone in the following 2 months.Intraocular pressures and graft fates of them were followed up.Results:In group A, IOPs were higher than 22mmHg in 58(25%)cases,while there were only 9 cases(5%)in group B whose IOPs were higher than 22mmHg.There was highly significant difference (P<0 001)between them.When we stop the 0 5% dexamethasone eye drop,most of the high IOPs fall down to the normal range in 1 2 weeks.There was no significant difference in the occurrence of graft rejecting between 2 groups.Conclusion:1% cyclosporin A eye drop can substitute the corticosteroid eye drop to prevent the occurrence of graft rejection and corticosteroid glaucoma.
出处 《中国实用眼科杂志》 CSCD 2000年第1期18-20,共3页 Chinese Journal of Practical Ophthalmology
关键词 环胞霉素A 皮质类固醇 穿透性 角膜移植 眼压 Cyclosporin A corticosteroid penetrating keratoplasty glaucoma
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参考文献3

  • 1李凤鸣.眼科全书(第1版)[M].北京:人民卫生出版社,1996.1932.
  • 2李凤鸣,眼科全书,1996年,1932页
  • 3Zhao J C,Am J Ophthalmology,1995年,119卷,189页

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