高渗氯化钠-醋酸钠溶液改善失血性休克大鼠微循环的作用

Hypertonic NaCl-NaAc improves the microcirculation in rats subjected to hemorrhagic shock

目的 :研究高渗氯化钠 -醋酸钠溶液对失血性休克大鼠微循环的作用。方法 :SD大鼠随机分为 7 5 %NaCl(HS)、5 %NaCl- 3 5 %NaAc(HSA)、0 9%NaCl(NS)三组。休克模型完成后 ,分别按 4mL/kg给药 ,观察脊斜肌微循环的变化。测定局部用药后 ,HS和HSA对血管内径的直接作用。结果 :HS较HSA更为显著升高MAP。给药 5min ,HSA、HS均能显著增加脊斜肌第三级细动静脉内径、血流速度、血流量和毛细血管开放数 ,减少红细胞聚集。 5min后HS组各指标恶化 ,显著低于HSA组。局部用药后 ,HSA较HS显著扩张第三级细动静脉内径。结论

AIM: To study the effects of hypertonic NaCl-NaAc on microcirculation in hemorrhage-shocked rats.METHODS: SD rats were randomized into three groups of 7 5% NaCl(hypertonic saline, HS),5% NaCl-3 5% NaAc(hypertonic sodium acetate, HSA) and 0 9% NaCl(normal saline, NS) 4 mL/kg HS,HSA or NS was given intravenously following hemorrhagic shock The microcirculation of spinotrapezius muscle was observed RESULTS: HS increased mean aortic pressure more significant than HSA Variables including arteriolar and venular diameter,velocity and volumetric flow rate and open capillaries were increased and erythrocyte aggregation was decreased in 5 min after resuscitation with both HS and HSA solutions 5 min later,variables were deteriorated in HS group After local treatment, arteriolar and venular diameters were dilated significantly in HSA group CONCLUSION:HSA had superior effects to HS in improving microcirculation of hemorrhage-shocked rats