62例冠心病病人抗心磷脂抗体的研究

Study on anticardiolipin antibodies (ACA) in patients with coronary heart disease

目的 :为了研究冠心病的病因、发病机理 ,提供临床诊断依据。方法 :采用酶联免疫吸附法( ELISA) ,对临床上 62例冠心病病人及 40例正常人进行了抗心磷脂抗体 ( ACA)的 Ig G、Ig M和Ig A的血清学检测。结果 :冠心病病人组的血清 Ig G- ACA和 Ig M- ACA显著高于正常对照组的Ig G- ACA和 Ig M- ACA水平。结论

Objective In order to investigate the pathogenesis and the pathological,physiological mechanisms and to provide experimental data for clinical diagnosis.Methods ACA were determined in 62 coronary heart disease patients and 40 controls by an enzyme linked immunosorbents assay.Results The results showed that IgG ACA and IgM ACA in patients with coronary heart disease were higher than those of normal ( P <0 01, P <0 05),and IgG ACA in patients with AP was higher than that of normal ( P <0 05).The ACA positive rate of AMI group was 34.4%,and that of AP group was 16.7%.These were higher than those of normal group ( P <0 05).Conclusion These results suggest that there is some relation between ACA and the coronary heart disease.