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多潜能干细胞在视网膜变性疾病中的研究现状 被引量：1

Current studies on induced pluripotent stem cells in retinal degenerative diseases
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摘要 视网膜变性疾病是一组由视网膜光感受器细胞变性、凋亡所致的严重致盲性眼病，至今仍无彻底的根治方法。多潜能干细胞是一种通过将体细胞重编程为类似胚胎干细胞的多潜能细胞，具有无限增殖、多向分化潜能和记忆能力等特点。目前有不少研究者将多潜能干细胞诱导分化为视网膜细胞，并应用于视网膜疾病的细胞移植治疗、发病机制研究及药物毒性评价等方面，这将为视网膜变性疾病的治疗提供新的研究思路和方法。 Retinal degeneration diseases are a group of severe eye diseases that can lead to blindness. They are characterized by degeneration and apoptosis of photoreceptor cells and still lacking effective therapeutic procedures. Pluripotent stem cells （induced pluripotent stem cells, iPS cells） obtained from somatic cell reprogramming are similar to the embryonic stem cells （embryonic stem cells, ES cells ） , which have unlimited proliferation, differentiation and memory characteristics. Retinal cells from iPS cells have been used in cell transplantation for the treatment of retinal diseases, for the study of pathogenesis and drug toxicity evaluation in retinal degenerative diseases. This may provide new ideas and novel procedures for the treatment of retinal degenerative diseases in the future.
作者 朱佳丽 郑钦象 李文生
机构地区 温州医学院附属眼视光医院
出处 《中华眼科杂志》 CAS CSCD 北大核心 2012年第4期374-378,共5页 Chinese Journal of Ophthalmology
关键词 视网膜变性 多潜能干细胞 细胞移植 药物评价 Retinal degeneration Induced pluripotent stem cells Cell transplantation Drug evaluation
分类号 R774.1 [医药卫生—眼科]
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参考文献34

  • 1Maclaren RE,Pearson RA,Macneil A. Retinal repair by transplantation of photoreceptor precursors[J].Nature,2006.203-207.
  • 2Lamba DA,Gust J,Reh TA. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice[J].Cell Stem Cell,2009.73-79.doi:10.1016/j.stem.2008.10.015.
  • 3Park IH,Arora N,Huo HG. Disease-specific induced pluripotent stem cells[J].Cell,2008,(5):877-886.doi:10.1016/j.cell.2008.07.041.
  • 4Polo JM,Liu S,Figueroa ME. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells[J].Nature Biotechnology,2010.848-855.doi:10.1038/nbt.1667.
  • 5Takahashi K,Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors[J].Cell,2006,(4):663-676.doi:10.1016/j.cell.2006.07.024.
  • 6Takahashi K,Tanabe K,Ohnuki M. Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J].Cell,2007.861-872.doi:10.1016/j.cell.2007.11.019.
  • 7Yu J,Vodyanik MA,Smuga-Otto K. Induced pluripotent stem cell lines derived from human somatic cells[J].Science,2007,(5858):1917-1920.doi:10.1126/science.1151526.
  • 8刘爽,段恩奎.诱导产生多能性干细胞(iPS细胞)的研究进展[J].科学通报,2008,53(4):377-385. 被引量：11
  • 9申红芬,姚志芳,肖高芳,贾俊双,肖东,姚开泰.诱导性多潜能干细胞(iPS cells)——现状及前景展望[J].生物化学与生物物理进展,2009,36(8):950-960. 被引量：34
  • 10Ning Sun,Michael T,Longaker. Human iPS cell-based therapy considerations before clinical applications[J].Cell,2010.880-885.

二级参考文献35

  • 1Czyz J,Wiese C,Rolletschek A,et al.Potential of embryonic and adult stem cells in vitro.Biol Chem,2003,384:1391-1409.
  • 2Takahashi K,Yamanaka S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblaat cultures by defined factors.Cell,2006,126:663-676.
  • 3Okita K,Ichisaka T,Yamanaka S.Generation of germlinecompetent induced pluripotent stem cells.Nature,2007,448:313-317.
  • 4Maherali N,Sridharan R,Xie W,et al.Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.Cell Stem Cell,2007,1:55-70.
  • 5Wernig M,Meissner A,Foreman R,et al.In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.Nature,2007,448:318-324.
  • 6Takahaahi K,Tanabe K,Ohnuki M,et al.Induction of pluripotent stem cells from adult human fibroblasts by defined factors.Ce11,2007,131:861-872.
  • 7Nakagawa M,Koyanagi M,Tanabe K,et al.Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.Nat Biotechno1,2008,26:101-106.
  • 8Yoshida Y,Takahashi K,Okita K,et al.Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells.Cell Stem Cell,2009,5:237 -241.
  • 9Yu J,Hu K,Smuga-Otto K,et al.Human induced pluripotent stem cells free of vector and transgene sequences.Science,2009,324:797-801.
  • 10Park IH,Arora N,Huo H,et al.Disease-specific induced pluripotent stem cells.Cell,2008,134:877-886.

共引文献42

同被引文献22

  • 1Yang J D, Cheng-Huang, Wang J C, et al. The isolation and cultivation of bone marrow stem cells and evaluation of differences for neural-like cells differentiation under the induction with neurotrophic factors [ J ]. Cytotechnology, 2014, 66(6) : 1007 - 1019.
  • 2Beltran W A, Cideciyan A V, Lewin A S, et al, Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa[ J]. Proc Natl Acad Sci U S A, 2012, 109(6) : 2132-2137.
  • 3Bonilha V L, Rayborn M E, Bell B A, et al. Histopathological comparison of eyes from patients with autosomal recessive retinitis pigmentosa caused by novel EYS mutations [ J ]. Graefes Arch Clin Exp Ophthalmol, 2015, 253(2): 295-305.
  • 4Inayat S, Rountree C M, Troy J B, et al. Chemical stimulation of rat retinal neurons: feasibility of anepiretinal based prosthesis [ J/OL ]. J Neural Eng, 2015, 12 ( 1 ) : 016010. doi: 10. 1088/1741 -2560/12/1/016010. Epub 2014 Dec 11.
  • 5Meirelles S H, Barreto A S, Buscacio E S, et al. Retinitis pigmentosa with concomitant essential iris atrophy and glancoma-case report [ J ]. Clin Ophthalmol, 2015, 26(9) : 2139 -2145.
  • 6Ikeda Y, Suzuki E, Kuramata T, et al. Development and evaluation of a visual aid using see-through display for patients with retinitis pigmentosa[ J]. Jpn J Ophthalmol, 2015, 59 (1) : 43 -47.
  • 7Donnelly C J, Park M, Spillane M, et at. Axanally synthesized 13-actin and GAP-43 proteins support distinct modes of axonal growth [J]. J Neurosci, 2013, 33(8) : 3311 -3322.
  • 8Rubio-Peita K, Fontrodona L, Aristizabal-Corrales D, et al. Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegansuncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis [J]. RNA, 2015, 21(12) : 2119 -2131.
  • 9Ogino K, Oishi M, Oishi A, et al. Radial fundus autofluorescence in the periphery in patients with X-linked retinitis pigmentosa[ J]. Clin Ophthalmol, 2015, 17(9) : 1467 - 1474.
  • 10Sorrentino F S, Bonifazzi C, Peril P, et al. The role of the endothelin system in the vascular dysregulation involved in retinitis pigmentosa [J/OL]. J Ophthalmol, 2015, 2015: 405234. doi: 10. 1155/ 2015/405234. Epub 2015 Nov 3.

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中华眼科杂志
2012年 第4期

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