复方丹参滴丸对冠心病患者血清超敏-C反应蛋白、脂联素和尿酸水平的影响

Influence of compound Danshen dripping pill on serum high sensitivity C-reactive protein,adiponectin and uric acid of coronary heart disease patients

目的观察冠心病患者复方丹参滴丸治疗前后血清超敏-C反应蛋白(hs-CRP)、脂联素(APN)和尿酸(UA)水平的变化。方法选取冠心病患者64例,随机分为观察组和治疗对照组,每组32例;并选取同期在本院体检的健康人30例为健康对照组。观察组和治疗对照组均给予美托洛尔、肠溶阿司匹林、硝酸甘油注射液等常规治疗。观察组在常规治疗基础上给予复方丹参滴丸。治疗前后采集各组清晨空腹肘静脉血,检测血清hs-CRP、APN和UA水平。结果观察组总有效率(93.75%)明显高于治疗对照组(68.75%)(P<0.05)。治疗前,观察组和治疗对照组患者血清APN明显低于健康对照组(P<0.01),hs-CRP和UA水平明显高于健康对照组(P<0.01);观察组血清hs-CRP、APN和UA水平与治疗对照组比较均无明显差异(P>0.05)。治疗后,观察组和治疗对照组血清APN均明显高于治疗前(P<0.01,P<0.05),血清hs-CRP和UA水平均明显低于治疗前(P<0.01,P<0.05),且观察组血清APN明显高于治疗对照组(P<0.01),hs-CRP和UA水平明显低于治疗对照组(P<0.01)。治疗后观察组血清hs-CRP、APN和UA水平与健康对照组比较差异均无统计学意义(P>0.05);治疗后治疗对照组血清hs-CRP、APN和UA水平与健康对照组比较差异均有统计学意义(P<0.05)。结论血清hs-CRP、APN和UA水平的变化可能与冠心病的发生、发展有一定关系。复方丹参滴丸可有效降低血清hs-CRP、UA及升高血清APN水平,改善冠心病患者的预后。

Objective To observe the changes of serum high sensitivity C-reactive protein（hs-CRP）,adiponectin（APN） and uric acid（UA） of coronary heart disease（CHD） patients before and after treatment by compound Danshen dripping pill. Methods Sixty-four CHD patients were divided into observation group（n=32） and treatment control group（n=32） randomly.Thirty healthy people were selected as health control group.The CHD patients in both groups were given metoprolol,aspirin and nitroglycerin injection.Based on these,the patients in observation group were given compound Danshen dripping pill.Fasting venous blood was collected from the each group before and after treatment,and the levels of serum hs-CRP,APN and UA were detected. Results The total efficiency in observation group was significantly higher than that in control group（93.75% vs 68.75%,P0.05）.Before treatment,the levels of serum APN in the observation group and treatment control group were significantly lower than those in health control group（P0.01）,and the levels of serum hs-CRP and UA were significantly higher than those in health control group（P0.01）;there were no differences of serum hs-CRP,APN and UA between observation group and treatment control group（P0.05）.After treatment,the levels of serum APN in observation group and treatment control group were significantly higher than that before treatment（P0.01,P0.05）,the levels of serum hs-CRP and UA were significantly lower than those before treatment（P0.01,P0.05）;the level of serum APN in observation group was significantly higher than that in treatment control group（P0.01）,the levels of serum hs-CRP and UA were significantly lower than those in treatment control group（P0.01）;and there were no differences of serum hs-CRP,APN and UA between observation group and health control group（P0.05）;but there were significant differences of serum hs-CRP,APN and UA between treatment control group and health control group（P0.05）. Conclusion The changes of serum hs-CRP,APN and UA may be related to the occurrence and development of CHD,compound Danshen dripping pill can effectively reduce the serum hs-CRP,UA and raise serum APN,it can improve the prognosis of CHD.