纳米支架与关节软骨重建

Effect of nanostructure scaffolds on articular cartilage reconstruction

背景:纳米羟基磷灰石因具有与骨组织中天然羟磷灰石晶体尺寸相关的特性以及具有良好的生物相容性和骨传导性,被广泛用于骨组织工程。目的:对纳米支架材料的性能进行阐述,探讨仿生多层纳米支架构建和纳米支架体内试验研究的新进展。方法:由作者应用计算机检索PubMed数据库及CNKI数据库1979/2011,在英文标题和摘要中以"cartilage,nano"和"cartilage,nanofiberornanofibrous"检索,中文文献检索以"软骨,纳米,支架"为关键词,选择内容与纳米支架、软骨损伤修复与软骨组织工程相关的文章,同一领域文献则选择近期发表或发表在权威杂志文章,共纳入50篇文献。结果与结论:软骨自我修复能力有限,软骨组织工程作为一种新治疗手段为其治愈提供了可能,纳米支架则以其优越的性能成为软骨组织修复的重要生物材料,纳米支架的仿生分层设计与制备及其生物性能的最优化,以及大宗样本临床试验的缺乏成为制约纳米支架材料应用于临床软骨缺损修复的关键问题。

BACKGROUND：Nano-hydroxyapatite is widely used in bone tissue engineering as it has the size-related properties with natural nano-hydroxyapatite crystal,as well as its good biocompatibility and conductibility.OBJECTIVE：To describe the characteristics of nanostructure scaffolds,and to investigate the biomimetic multilayered nanostructure scaffolds construction and its new research progress in vivo.METHODS：The PubMed database（Http：//www.ncbi.nim.nih.gov/PubMed） and CNKI database（www.cnki.net/index.htm） were retrieved for articles from 1979 to 2011 by computer.The English key words were ＂cartilage,nano＂ and ＂cartilage,nanofiber or nanofibrous＂,and the Chinese key words were ＂cartilage,nano,scaffold＂.A total of 50 articles were included which related to nanostructure scaffolds,cartilage regeneration and cartilage tissue engineering,and for articles in the same field,those published recently or in authorized journals were selected.RESULTS AND CONCLUSION：Cartilage tissue engineering provided the possible regeneration of damaged cartilage which has limited self-repair abilities.Nanostructure scaffolds are superior to others for their excellent functions and play an important role in repairing the cartilage tissue.At present,the biomimetic multilayered designing of nano-scaffolds,developing in its functions,and the great need of clinical studies have become the most significant factors of tissue engineering.