非小细胞肺癌患者血清血管生成素-2水平及其临床意义

The Levels and Clinical Significance of Angiopoietin-2 in Serum of Patients with Non-Small Cell Lung Cancer

目的探讨非小细胞肺癌(NSCLC)患者血清血管生成素-2(Ang-2)水平及其临床意义。方法采用酶联免疫吸附(ELISA)法测定102例NSCLC患者和60例良性肺部疾病患者血清Ang-2水平,并以90例健康人血清作为对照,分析Ang-2与NSCLC临床病理特征及预后的关系。结果 NSCLC组患者血清Ang-2水平高于良性肺部疾病组和健康对照组(P均<0.01)。Ⅲ～Ⅳ期患者血清Ang-2水平高于Ⅰ～Ⅱ期患者;有淋巴结转移患者高于无淋巴结转移患者;手术前高于手术后;复发后高于复发前;存活期1 a以内患者低于存活期1 a及以上患者,各组比较差异均有统计学意义(P均<0.01)。结论血清Ang-2水平与肿瘤活动度密切相关,能够反映疾病的严重程度,也可用于判定手术效果、监测复发和评估预后等。

Objective To explore the levels and clinical significance of angiopoietin-2 （Ang-2） in serum of patients with non-small cell lung cancer （NSCLC）. Methods The serum Ang-2 levels of 102 cases of NSCLC ,60 ca- ses of benign lung disease and 90 cases of healthy control were measured by enzyme linked immunosorbent assay （ELISA）. Results The serum Ang-2 levels of the NSCLC group were significantly higher than those of the benign lung disease and the healthy control group （P 〈 0.01）. The serum Ang-2 levels of m-r~ stage NSCLC,NSCLC with lymph node metastasis, NSCLC before operation,recrudescent NSCLC or NSCLC with survival below one year were relatively higher than those in the I - 11 stage, without lymph node metastasis, after operation, no recrudescent or sur- vival over one year, there were significant differences （P 〈 0.01 ）. Conclusion Ang-2 levels in serum are closely related to the tumor activity and reflects the severity of the disease, can also be used to determine the effects of sur- gery, monitoring of recurrence and evaluation of prognosis.