促纤维增生性黑色素瘤临床病理学分析

The Clinicopathological Analyses of Desmoplastic Melanoma

目的探讨促纤维增生性黑色素瘤(DM)的临床病理学特征。方法回顾性分析2例DM患者的临床及病理资料,并复习相关文献。结果 DM多见于男性,好发于日光暴露部位皮肤,多表现为无痛性硬斑,瘤细胞常杂乱无章地分布于成熟的胶原束内或之间,在肿瘤内或肿瘤周边常见小灶状淋巴细胞浸润。免疫组化:瘤细胞S-100阳性。结论 DM是一种少见的肿瘤,临床易误诊为其他梭形细胞肿瘤。

Objective To explore the clinicopathological features of desmoplastic melanoma （DM）. Methods The clinicopathological data of 2 patients with DM were observed, and the related literatures were reviewed. Results DM was usually found in the males and skin exposed to the sunshine. It was manifested as the painless hard spot. The tumor cells spread in or around the mature collagen fiber irregularly. It was usually found the focal lymphocytic infiltration in or around the tumor. The tumor cells were positive for S-100. Conclusion DM is a kind of rare tumor. It is easily misdiagnosed as other kinds of spindle cell tumors.