摘要
目的:探讨食管癌联合术前放疗及术后化疗疗效。方法:选择2006年1月-2008年1月笔者所在医院收治的56例食管癌患者为观察组,行术前放疗和术后化疗治疗;选择同期收治56例食管癌患者单纯放疗为对照组,单纯行放疗。比较两组患者的疗效。结果:所有患者均随访3年,观察组3年生存率为50.00%,对照组3年生存率为30.36%,两组比较差异有统计学意义(P<0.01)。观察组治疗3年ⅡA、ⅡB、Ⅲ期的生存率分别为75.00%、43.48%、36.00%,对照组组分别为37.50%、21.74%、20.00%,两组比较差异有统计学意义(P<0.01)。观察组纵隔转移率为14.29%,与对照组的46.43%相比,差异有统计学意义(P<0.01)。其他转移部位比较差异无统计学意义(P>0.05)。结论:术前放疗联合术后化疗有助于提高肿瘤局部控制率,减少术后癌肿复发,能够延长患者的生存期,在临床上具有积极指导意义,值得推广。
Objective:To investigate esophageal cancer combined with preoperative radiotherapy and postoperative chemotherapy.Methods:From January 2006 to January 2008 56 cases of esophageal cancer patients treated in the observation group,preoperative radiotherapy and postoperative chemotherapy;Choosing the same period 56 cases of esophageal cancer patients treated with radiotherapy alone as the control group,radiotherapy alone.Results:All patients were followed up for 3 years to observe the 3-year survival rate was 50%.Control group,3-year survival rate was 30.36%,compared the two groups with significant differences(P〈0.01).Observation group treatment for 3 years Ⅱ A,Ⅱ B,Ⅲ period survival rates were 75.00%,43.48%,36.00%;Control group group were 37.50%,21.74%,20.00%,compared the two groups with significant differences(P〈0.01).Observation group,mediastinal metastasis was 14.29%,compared with the control group rate of 46.43% compared to the mediastinal shift,a significant difference(P〈0.01).Other metastatic sites were no significant differences(P〈0.05).Conclusion:Preoperative radiotherapy combined with chemotherapy after surgery to help improve local tumor control rate and reduce the postoperative recurrence of cancer can prolong survival of patients in clinical practice has a positive significance,worthy of promotion.
出处
《中外医学研究》
2012年第11期14-15,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
食管癌
术前放疗
术后化疗
Esophagus
Preoperative radiotherapy
Postoperative chemotherapy