间充质干细胞移植治疗多发性硬化的研究进展

Research progress in mesenchymal stem cells transplantation for treatment of multiple sclerosis

背景:多发性硬化是中枢神经系统白质脱髓鞘性疾病,其确切的病因和发病机制尚不清楚。其临床表现复杂多变,传统治疗均不能延缓疾病的进程。目的:综述间充质干细胞移植治疗多发性硬化的研究进展,并提出目前间充质干细胞使用方面许多亟待解决的问题。方法:以"mesenchymal stem cells,encephalomyelitis,autoimmune,experimental,multiple sclerosis"为英文检索词,检索Kjmed数据库中2000/2011发表的相关文章。纳入与间充质干细胞治疗多发性硬化研究相关的文献。结果与结论:共检索到104篇文献,排除无关重复的文献,保留33篇进行综述。目前研究证实间充质干细胞是一种具有免疫调节及神经修复功能的多能干细胞,同时间充质干细胞在治疗多发性硬化方面显示了初步的治疗效果。

BACKGROUND：Multiple sclerosis（MS） is a neurodegenerative disease of the central nervous system and has a complex etiology that is not fully understood.The clinical course of MS is heterogeneous,and the traditional therapeutic interventions for MS have not been convincingly shown to change the natural course of the disease.OBJECTIVE：To summarize the mechanism and application of mesenchymal stem cells transplantation for the treatment of multiple sclerosis and raise some questions that should be settled.METHODS：Kjmed databases were searched by the first author using Key words of ＂mesenchymal stem cells,encephalomyelitis,autoimmune,experimental,multiple sclerosis＂ in English from 2000 to 2011.Literatures that related with the mesenchymal stem cells for the treatment of MS were included,and the repetitive researches were excluded.RESULTS AND CONCLUSION：A total of 104 documents were retrieved,and 33 articles were retained after deleting unrelated and repetitive ones.To date,the research had showed that mesenchymal stem cells were multipotent stem cell with the characteristics of immune regulatory and neuroprotective properties,and had showed the initial therapeutic effect on the treatment of MS.