MRI扫描及体表简单参数评估绝经妇女肌肉间的脂肪含量

Evaluation of intermuscular fat content in menopausal women by magnetic resonance imaging scanning and simple surface parameters

背景:绝经妇女常伴有全身肌肉间脂肪增加,国际上可用于测量全身肌肉间脂肪的方法有CT和MRI,但成本均比较昂贵,且CT具有放射性等缺点,不宜广泛应用于临床。目的:使用体表简单参数(人体学和血清学指标等)评估绝经妇女MRI扫描肌肉间脂肪含量,以期提高检测效率,节省医疗成本。方法:自然绝经的妇女60名,分为代谢综合征组和非代谢综合征组。测量人体学指标(体质量,肱三头肌皮褶厚度等),血清学指标(三酰甘油等),使用生物电阻抗仪测量全身脂肪含量。依既往研究成果选取小腿中部单层图像分析计算小腿中部以及全身肌肉间脂肪含量。将体表简单参数与MRI测量结果进行多元回归分析。结果与结论:①全身脂肪含量超量(全身脂肪含量百分比>30%)、代谢综合征的发生率分别为88.3%,28.3%。②消除年龄、绝经年限及雌二醇水平的影响,小腿中部肌肉间脂肪面积以及全身肌肉间脂肪体积与三酰甘油、空腹血糖、收缩压、舒张压呈正相关,与高密度脂蛋白胆固醇呈负相关。③与全身肌肉间脂肪体积最相关的指标为全身脂肪含量。④初步建立使用体表简单参数评估绝经妇女肌肉间脂肪含量的方程。提示全身肌肉间脂肪体积是绝经妇女发生代谢综合征的危险因素。

BACKGROUND：Menopausal women often appear with the increase of intermuscular adipose tissue mass（IMAT） content.International methods that used to measure the IMAT content are CT and magnetic resonance imaging（MRI）.Because the costs are more expensive and CT has disadvantages in radioactivity,so they are not suitable to be widely used in clinical.OBJECTIVE：To estimate the intermuscular fat content which measure by MRI from simple surface parameters（anthropometric and serological indicators） in menopausal women in order to improve the detection efficiency and save the health care costs.METHODS：A total of 60 naturally menopausal women were divided into metabolic syndrome group and non-metabolic syndrome group.The anthropometric indicators and serological indicators were measured.IMAT content was detected using bioelectrical impedance analyzer.According to previous research results,the middle leg area and IMAT content were measured by single cross-sectional MRI of the middle leg area.The multiple-regression analysis was conducted between measurement results of MRI and simple surface parameters.RESULTS AND CONCLUSION：①IMAT content was excess（percentage of IMAT content 30%）.The incidence of metabolic syndrome was 88.3% and 28.3%.②Middle leg IMAT area and total IMAT content had a positive correlation with triglyceride,systolic pressure,diastolic pressure and fasting plasma glucose,while a negative correlation with high density lipoprotein-cholesterol,when age,years since postmenopause and the level of estradiol were eliminated.③Fat content of the whole body had a strongest relationship with the IMAT.④The equation which was used to estimate IMAT from anthropometric simple surface parameters in menopausal women was initially established.It is indicated that the total IMAT content is a risk factor for metabolic syndrome in menopausal women.