IL-6和TNF-α在子宫内膜异位症合并不孕症患者血清和腹腔液中的表达

Expression levels of interleukin-6 and tumor necrosis factor-α in patients with endometriosis and infertility

目的:探讨血清白介素-6(IL-6)和肿瘤坏死因子(TNF-α)在子宫内膜异位症(EMS)合并不孕症患者中的表达情况。方法:研究分为两组:EMS合并不孕症组(40例)和正常对照组(40例),采用ELISA方法分别检测血清和腹腔液中的IL-6和TNF-α水平。结果:EMS合并不孕症组血清、腹腔液中IL-6、TNF-α水平明显高于对照组(P<0.001)。结论:IL-6、TNF-α在EMS引起的不孕症的发生、发展中发挥着重要作用。

Objective： To explore the expression levels of interleukin - 6 （ IL - 6） and tumor necrosis factor - a （ TNF - ct） in infertility patients with endometriosis. Methods：There were 2 groups： the endometriosis with infertility group and the control group. The serum and peritoneal fluid levels of IL - 6 and TNF - o~ were detected by ELISA. Results： Both of the serum and peritoneal fluid levels of IL - 6 and TNF - ct in endometriosis group with infertility were significantly higher than the control group （ P 〈 0. 001 ）. Conelusions： The serum 1L - 6 and TNF - ct play an important role in genesis and development of endometriosis with infertility.