喹硫平与丙戊酸镁治疗双相障碍躁狂发作的对照研究

A control study of Quetiapine and Magnesium valproate for the treatment of bipolar disorder

目的:探讨喹硫平对双相障碍躁狂发作的疗效及依从性。方法:将100例双相障碍躁狂发作住院患者随机分为两组,分别给予喹硫平与丙戊酸镁治疗,疗程为8周。用倍克-拉范森躁狂量表(BRMS)评定疗效,用副反应量表(TESS)评定不良反应。结果:治疗后喹硫平组BRMS分值明显下降(基线为32±7;第8周5±2);丙戊酸镁组BRMS分值也明显下降(基线为31±7;第8周6±2)。喹硫平组与丙戊酸镁组从第2周BRMS分值下降都比较明显,疗效无显著性差异(t=2.875,P>0.05);第8周末喹硫平组临床痊愈率为52%,丙戊酸镁组临床痊愈率为50%,(x2=1.357,P>0.05)未见明显差异,不良反应发生率无明显差异,均在用药早期出现。喹硫平组随着治疗延续而逐渐耐受,临床脱落率为8%,而丙戊酸镁组随着剂量增高而上述症状加重,临床脱落率为18%,两组脱落率有显著性差异(P<0.01)。结论:喹硫平与丙戊酸镁对双相躁狂发作皆有较好疗效,疗效相当。喹硫平治疗依从性更高。

Objective ：To discuss the effect of cerebral palsy on the quality of life in Children. Methods：From Jun 2010 to Jun 2011, selected 60 cases with cerebral palsy as search group, 60 cases with respiratory tract infection as common disease group, and 60 healthy children as control group. The quality of life of three groups were evaluated and compared. Results： Each items score and the general score had significant difference in three groups （P 〈0.01 or P 〈0.05）, and each items score and the general score in search group were lower than common disease group and control group, which had significant difference （ P 〈 0.01 ）. The school performance score in common disease group was lower than control group （ P 〈 0.05 ）, and there were no significant difference in other items score （ P 〉 0.05 ）. Not enrollment rate in search group was obviously higher than common disease group and control group （ P 〈 0.01 ）. And the ratio of kindergarten and primary school pupil in search group were lower than in common disease group and control group （ P 〈 0.01 ）. There were no significant difference between common disease group and control group （ P 〉 0.05）. Conclusions： Cerebral pal- sy has a great effect on the quality of life in children. The rehabilitation for children with cerebral palsy should improve each filed of the quality of life.