反义寡核苷酸技术与眼科疾病

Antisense oligonucleotide technology and ophthalmic diseases

角膜损伤、白内障、青光眼、增殖性玻璃体视网膜病变都是可以致盲的眼科疾病,对此类疾病目前主要是采取药物及手术治疗,而手术不能阻止它们的再发。近年来,越来越多的研究者发现,反义寡核苷酸技术在以上眼科疾病的发生发展中起重要作用,并试图探索出一条新的防治途径。现就近年来国内外对于反义寡核苷酸技术与角膜损伤、白内障、青光眼、增殖性玻璃体视网膜病变的研究现状进行简要概述。

Corneal injury, cataract, proliferative vitreoretinopathy and glaucoma can all be blindness-causing eye disease, such diseases currently rely mainly on drugs and surgical treatment, but surgery can not prevent their recurrence. In recent years, many researchers discovered that antisense oligonucleotide technology played an important role in eye diseases of the above, and tried to explore a new way to prevent these diseases. This paper briefly reviewed the current research situation of antisense oligonucleotide technology and corneal injury, cataract, proliferative vitreoretinopathy, glaucoma.