早期糖尿病患者黄斑区厚度与相关生化指标的关系

Relationship of macular area thickness and related biochemical indicators in patients with early diabetes

目的:研究早期糖尿病患者黄斑区视网膜厚度与相关生化指标的关系。方法:糖尿病组40例40眼(男、女各20例),对照组40例40眼(男、女各20例),应用OCT测量黄斑区视网膜厚度,应用相关生化仪检测糖尿病组的尿微量白蛋白(mAlb)、糖化血红蛋白比(HbA1c)、C-肽(C-PR)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)的值。比较两组黄斑区视网膜的厚度,分析糖尿病组黄斑区厚度与相关生化指标的关系。结果:糖尿病组所选患者黄斑区厚度比正常组大(P<0.01),黄斑区视网膜厚度与尿微量白蛋白(mAlb)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)呈正相关(P<0.05);与高密度脂蛋白(HDL)呈负相关(P<0.05);与糖化血红蛋白比(HbA1c)和C-肽(C-PR)无相关性(P>0.05)。结论:对于早期糖尿病患者,检测黄斑区厚度和尿微量白蛋白(mAlb)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)的变化,有利于糖尿病早期并发症的预测。

AIM： To study the relationship of retinal thickness at macular area and related biochemical indicators in early diabetic patients. METHODS：Diabetes group had 40 cases （40 eyes）, male and female 20 cases of each）.The control group had 40 cases （40 eyes, male and female 20 cases of each）, optical coherence tomography （OCT） was applied to measuring the retinal thickness at macular area. Related biochemical analyzer was used to test microalbuminuria （mAIb）, glycated hemoglobin （HbA1c）,c-peptide （C-PR）,total cholesterol （TC）,triglycerides （TG）,low density lipoprotein （LDL）,and high-density lipoprotein （HDL） values in the diabetes group. Two groups of retinal thickness at macular area were compared and the relationship of macular area thickness and related biochemical indicators in the diabetes group was analysed. RESULTS： Macular area in the selected diabetes group patients was thicker than that in normal group, which was positively correlated with mAIb, TC, TG, and LDL（P0.05） , negatively with HDL（P0.05） and uncorrelated with HbA1c and C-PR（P0.05）. CONCLUSION：For patients with early diabetes, detecting the macular area thickness and mAIb, TC, TG, LDL, HDL changes is conductive to the early prediction of complications of diabetes.