脑室灌洗治疗小儿神经外科术后颅内感染的效果分析

Analysis of the curative effect of intraventricular antibiotic lavation on intracranial infections in children after craniotomy

目的探讨脑室内灌洗抗生素治疗小儿神经外科术后颅内感染的临床效果。方法回顾性分析54例小儿神经外科术后颅内感染患者的临床资料。54例患者均经受了经脑室手术切除病变和置管脑室外引流。这54例颅内感染的小儿患者中,20例采用脑室内灌洗抗生素治疗,34例采用静脉输注抗生素治疗。结果颅内感染的持续时间脑室内灌洗组为(5.55±2.25)d,静脉内给药组为(11.25±3.48)d,两者相较,相差显著(P<0.05)。结论小儿神经外科涉及脑室系统的手术,可留置脑室外引流管,一旦发生颅内感染,抗菌素脑室内灌洗可以有效控制颅内感染程度和持续时间,明显改善患者预后。

Objective To explore the curative effect of intraventricular antibiotic lavation on intracranial infection after the craniotomy in children.Methods The clinical data of 54 children intracranial infection after the craniotomy,of whom,20 were treated by the intraventricular antibiotic lavation an 34 by the intravenous infusion of antibiotics,were analyzed retrospectively.The transventricular microsurgery for the intracranial lesions and external ventricular drainage were performed in all the children.Results The duration of the intracranial infection [（5.55±2.25）days] was significantly shorter in the intracranial lavation group than that [（11.25± 3.48）]days in the intravenous infusion group （P0.05）.Conclusion The intraventricular antibiotic lavation could may better control postcraniotomy intracranial infection compared to the intravenous infusion of antibiotics in children.