口服多潘立酮治疗早产儿喂养不耐受对心室复极的影响分析

Effect of Domperidone on Ventricular Repolarization in Treating Premature Infants with Feeding Intolerance

目的探讨多潘立酮治疗早产儿喂养不耐受对心室复极的影响,为临床安全用药提供依据。方法 41例喂养不耐受早产儿给予口服多潘立酮混悬液,监测用药前后心电图Q-T间期的变化。结果 41例喂养不耐受早产儿口服多潘立酮后治愈28例,好转8例,无效5例。心电图Q-T间期延长30 ms以上的9例(21.9%),其中Q-T间期>400 ms的1例(2.4%),无心律失常发生。结论口服多潘立酮可延长早产儿心室复极时间,建议临床应用多潘立酮过程中监测Q-T间期,警惕心律失常的发生。

Objective To analyze the effect of domperidone on ventricular repolarization when treating premature in- fants with feeding intolerance in order to provide evidence for the safe use of domperidone in clinical practices. Methods 41 pre- mature infants diagnosed with feeding intolerance were treated by domperidone suspension. Q - T interval of ECG was recorded be- fore and after the treatment. Results Among the 41 premature infants with feeding intolerance, 28 were cured, 8 were improved and 5 were ineffective after the treatment with domperidone suspension. 9 cases （21.9%） had prolonged Q -T interval more than 30 ms, among which 1 case （2. 4% ） had Q -T interval more than 400 ms. No arrhythmia occurred. Conclusion Taking domp- eridone orally can prolong ventricular repolarization of the premature infants, and Q - T interval and occurrence of arrhythmia should be monitored during the process of using domperidone in premature infants who were diagnosed with feeding intolerance.