脓毒症急性肾损伤发病机制的研究进展

Pathogenesis of acute kidney injury induced by sepsis

脓毒症急性肾损伤是脓毒症多器官功能障碍的表现之一。当出现急性肾损伤时，往往提示病情危重。脓毒症急性肾损伤主要与肾脏血流动力学改变、缺血再灌注损伤、直接的炎症损伤、凝血和血管内皮细胞功能紊乱及细胞凋亡等有关。

Acute kidney injury（AKI） induced by sepsis is one symptom of sepsis-induced multiple organ dysfunction, which indicates critical illness. The current study have found that many factors involved in AKI, including hemodynamic changes in renal, ischemia-reperfusion injury, direct inflammatory injury, coagulation and endothelial cell dysfunction, apoptosis and so on.