心脏型脂肪酸结合蛋白在急性心肌梗死诊断中的应用价值

The value of heart-type fatty acid-binding protein in early diagnosis of acute myocardial infarction

目的研究心脏型脂肪酸结合蛋白(H-FABP)对急性心肌梗死早期诊断的价值。方法 120例急性心肌梗死患者分别进行H-FABP方法和常规实验室检测方法(肌钙蛋白Ⅰ、肌酸激酶同工酶)测定,比较不同检测方法的诊断敏感性及准确性。结果 H-FABP检测法的诊断敏感性及准确性均明显高于常规的检测方法(P<0.05)。结论H-FABP对于急性心肌梗死的早期诊断具有较高的敏感性及准确性,可作为诊断早期急性心肌梗死的理想指标。

Objective To discuss the advantage and value of heart-type fatty acid-binding protein（H-FABP） in early diagnosis of acute myocardial infarction（AMI）.Methods One hundred and twenty patients with AMI were diagno-sed by H-FABP and conventional laboratory method（cTnⅠ,CK-MB） respectively,and then compare the diagnostic sensitivity and accuracy of these two kinds of detection methods.Results H-FABP detection sensitivity and accuracy of diagnosis were significantly higher than conventional detection methods（P0.05）.Conclusion H-FABP is more sensitive and specific in early diagnosis of AMI,which may has great potential as an excellent biochemical cardiac marker for early diagnosis of AMI.