DNA修复基因XRCC1-26304C>T多态性与口腔癌易感性关系的meta分析

Meta Analysis on DNA Repair Gene XRCC1-26304C>T Single Neucleotide Polymorphisms and Oral Cancer Susceptibility

目的:采用系统评价的方法综合分析DNA修复基因(X-ray cross-complementing group 1,XRCC1)26304C>T位点单核苷酸多态性与口腔癌易感性的关系。方法:检索PubMed(1966～2011.4)、EMBASE(1974～2011.4)、中国生物医学文献数据库CBM(1978～2011.3)、中国期刊全文数据库CNKI(1994～2011.3)等数据库收录的XRCC1-26304C>T单核苷酸多态性与口腔癌易感性的研究。以病例组和对照组等位基因分布的比值比(odds ratio OR)为效应指标,根据异质性检验结果,选择固定效应模型或随机效应模型对OR进行合并。结果:本次meta分析共纳入文献7篇,病例组1155例,对照组2036例。分析结果显示:突变纯合子(T/T)患口腔癌的风险与野生型纯合子(C/C)相比OR=1.46(0.93～2.28);隐性模式下,突变纯合子(T/T)患口腔癌的风险与野生型(纯合子+杂合子)(C/C)+(C/T)相比OR=1.30(0.84～2.00);显性模式下,突变个体(突变纯合子+突变杂合子)(T/T)+(C/T)患口腔癌的风险与野生型纯合子(C/C)相比OR=1.34(1.02～1.76)。按亚洲人群和高加索人群进行亚组分析,亚洲人群在显性模式下该位点的多态性与口腔癌易感性存在相关性OR=1.42(1.04～1.94),其它情况下均未发现相关性。结论:显性模式下携带XRCC1基因突变型(TT+CT)的亚洲人可能是口腔癌的易感人群,但需要更多的研究加以证实。

Objictive： To evaluate the relationship between X-ray cross-complementing group 1（XRCC1）gene single neucleotide polymorphisms and oral cancer susceptibility.Methods： By searching Medline,EMBSE,CBM and CNKI et al,we collect studies about DNA X-ray cross-complementing group 1（XRCC1） gene polymorphisms and oral cancer susceptibility.The odds ratios（OR） of variant allele of XRCC3-26304C〉T was calculated by using statistic software RevievMan5.0 and STATA11.0.Results： 7 case-control studies were identified for the meta-analysis,a total of 1155 cases and 2036 controls were included.In the（T/T）VS（C/C） group the odds ratio was 1.46（0.93-2.28）;For the recessive genetic model,in the（T/T）VS（C/C）＋（C/T） group the odds ratio was 1.30（0.84-2.00）;For the dominint genetic model,in the（T/T）＋（C/T）VS（C/C） group the odds ratio was OR=1.34（1.02-1.76）.Conclusion： In the dominant genetic mode,carrying XRCC1 gene mutations（TT ＋ CT） of Asians may be susceptible of oral cancer,but more researches are needed to confirm.