桉烷-4(15)-烯-1β,7α-二醇的不对称全合成

Asymmetric Total Synthesis of 4(15)-Eudesmene-1β,7α-diol

天然产物桉烷-4(15)-烯-1β,7α-二醇(Y019)从植物中间锦鸡儿中分离得到,初步的药理活性研究中发现具有抗稻瘟霉活性.我们从原料1,3-环己二酮出发以线性步骤11步反应9.4%的总产率,首次完成了天然产物桉烷-4(15)-烯-1β,7α-二醇的不对称全合成,为进一步的药理活性研究奠定了基础.

The natural product 4（15）-eudesmene-1β,7α-diol is isolated from Caragana intermedia.In the preliminary biological test,it showed anti-pyricularia oryzae P-2b activity.In order to get enough amount to support diverse biological test,the asymmetric total synthesis of this compound was completed in 11 linear steps with 9.4% yield.