乌司他汀对脓毒血症患者心肌肌钙蛋白I和D-二聚体的影响

Effects of Ulinastatin on cardiac troponin I and D-dimer in the patients with sepsis

目的:探讨乌司他汀对脓毒血症患者心肌肌钙蛋白I(cTnI)和D-二聚体(D-dimer)的影响。方法:严重脓毒血症和脓毒症休克患者41例,随机分为对照组和治疗组。观察治疗前及治疗后第1、2、3、4天血清cTnI和D-dimer的变化。结果:两组死亡率(对照组30%治疗组28.4%)及急性生理和慢性健康状况评分Ⅱ(APACHEⅡ)比较差异无统计学意义(P均﹥0.05)。治疗组cTnI和D-dimer下降幅度与对照组相比差异有统计学意义(P﹤0.05)。结论:乌司他汀可减轻脓毒血症患者心肌损伤程度,抑制微血栓形成,阻止继发性损伤。

Objective： To observe the effect of Ulinastatin（UTI） on cardiac troponin I（cTnI） and D-dimer level in the patients with sepsis.Methods： The study included 41 patients with severe sepsis and septic shock were included in the study.They were divided into routine therapy（n = 20） and UTI group（n = 21）.Cardiac troponin I（cTnI） and D-dimer were determined by ELISA assay before and after treatment.Results： There were no differences in total mortality and APACHEⅡ score between the two groups after the treatment（all P 0.05）.Group UTI had lower levels of cTnI and D-dimer than routine therapy.Conclusion： UTI can reduce the degree of myocardial injury,inhibit microthrombosis in the microcirculation and prevent the secondary damage of the patients with sepsis.