孟鲁司特联合酮替芬治疗小儿咳嗽变异性哮喘60例疗效观察

Clinical Study on Montelukast Combined with Betoken to Treat 60 Patients with Cough Variant Asthma in Children

目的:观察孟鲁司特钠咀嚼片联合酮替芬治疗小儿咳嗽变异性哮喘的临床疗效。方法:对照组60例口服酮替芬片,治疗组60例口服酮替芬片加用孟鲁司特钠咀嚼片。两组咳嗽症状消失后均停用酮替芬片,治疗组继续服用孟鲁司特钠咀嚼片,总疗程2个月。停药后随访1年,观察咳嗽复发、哮喘转化及不良反应情况。结果:治疗组疗效明显优于对照组,差异有显著性(P<0.05);在咳嗽症状复发数、典型哮喘转化率和不良反应方面,治疗组均比对照组明显降低(P<0.05)。结论:孟鲁司特钠咀嚼片联合酮替芬治疗小儿咳嗽变异性哮喘临床疗效好,不良反应少,值得临床推广使用。

Objective： To study the efficacy of montelukast combined with Ketotifen on the prevention of cough variant Asthma in children.Methods： 60 patients were treated with Ketotifen and montelukast sodium chewable tablets.Another 60 Patients who were taken Ketotifen orally served as control.After symptoms disappearing,Ketotifen treatment was ceased in both groups and montelukast administration continued till 2 months.Recurrence of cough,asthma conversion and adverse events had been followed up for 1 year.Results： The therapeutic efficacy in the treatment group was significantly higher than that in the control group（P 0.05）.The recurrent rate of cough asthma conversion and adverse events were less in the treatment group than those in the control group（P 0.05）.Conclusion： Montelukast combined with Ketotifen has better effect on cough variant asthma with little side effect in children.It is worthy of clinical promotion.