长期氧疗对慢性阻塞性肺疾病患者生存影响的六年随访研究

6-year follow-up study in COPD patients with long-term oxygen therapy

目的探讨长期氧疗对慢性阻塞性肺疾病患者6年生存率的影响。方法将103例慢性阻塞性肺疾病患者按照是否接受长期氧疗分为氧疗组（48例）和对照组（55例）。以患者死亡或者完成6年随访为研究终点，比较两组患者6年生存率、住院次数、健康相关的生活质量评分（SGRQ评分）。结果氧疗组住院次数[（8±5）次]少于对照组[（10±4）次]，其SGRQ评分[（47．3±11．8）分]低于后者[（53．2±13．1）分]，两组比差异有统计学意义（P〈0．05）；Kaplan—Meier分析结果表明，对照组患者6年生存率低于氧疗组（P〈0．05）。结论长期氧疗能够提高慢性阻塞性肺疾病患者6年生存率，减少住院次数，提高生活质量。

Objective To evaluate the impact of long-term oxygen therapy （LTOT） on 6-year survival rate of COPD patients. Methods From January 2001 to December 2002, a total of 103 inpatients with COPD were enrolled. They were assigned into two groups ： LTOT group （ receive LTOT） and control group（ not receive LTOT）. The follow-up time was 6 years. Results The 6-year survival rate of the control group was lower than the LTOT group（ log-rank test, X^2 = 4.36, P 〈 0.05 ）. The need of rehospitalization was lower [ （8 ± 5） vs. （ 10 ± 4）, t = 2. 25, P 〈 0.05 ] and the SGTQ score was better [ （47.3 ±11.8 ） vs. （53.2 ± 13.1 ）, t = 2. 38, P 〈 0.05 ] of the LTOT group than that of the control group. Conclusion LTOT can improve 6-year survival rate of COPD patients, reduce the need of rehospitalization and improve health-related quality of life.