血清瘦素、脂联素与心肌缺血再灌注损伤关系的研究进展

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摘要心肌缺血再灌注损伤是心血管疾病领域研究的重点与热点问题之一,大量研究资料显示血清瘦素、脂联素作为脂肪细胞因子通过与其受体结合不仅参与了糖脂、能量代谢,而且在心血管方面亦有作用,但其具体机制尚不明确。本文就近年来血清瘦素、脂联素与心肌缺血再灌注损伤的研究作一综述。

作者戴玲徐彤彤吕祥威

机构地区桂林医学院

出处《航空航天医学杂志》 2012年第3期382-383,共2页 Journal of Aerospace medicine

基金 2011广西省科技厅广西科学研究与技术开发计划项目课题(桂科攻1140003B-76) 2010广西医疗卫生重点科研课题(重2010050) 2011广西研究生教育创新计划项目(桂学位[2011]35号-558)

关键词血清瘦素脂联素心肌缺血再灌注损伤

分类号 R446.1 [医药卫生—诊断学]

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参考文献20

1Hausenloy DJ,Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury:targeting the reperfusion injury salvage kinase (RISK)-pathway[J].Cardiovascular Research,2004,(03):448-460.doi:10.1016/j.cardiores.2003.09.024.
2Zhang Y,Proenea R,Maffei M. Positional cloning of the mouse obese gene and its human homologue[J].Nature,1994,(6505):425-432.
3Ghilardi N,Skoda RC. The leptin receptor activates janas kinase and singnals for proliferation in a factor-depender all line[J].Mol Endoerinol,1997,(04):393-399.
4Derek J,Sang-bing Ong. The mitochondrial permeability transition pore as target for preconditioning and postconditioning[J].Basic Research in Cardiology,2009.189-202.
5徐彤彤(综述),陈蒙华(审校).心肌缺血-再灌注损伤的瘦素机制研究新进展[J].中国急救医学,2010,30(6):548-551. 被引量：14
6Quehenberger P,Exner M,Sunder-Plassmann R. Leptin induces endothelin-1 in endothelial cells in vitro[J].Circulation Research,2002,(05):711-718.
7CHu NF,Spiegelman D,Botamisligil GS. Plasma insulin,leptin and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogeniccardiovascular disease risk factors among men[J].Atheroclerosis,2001,(02):495-503.
8Fujimaki S,Kanda T,Fujita K. The significance of measuring plasma leptin in acute myocardtial infarction[J].Journal of Internal Medicine,2001,(02):108-113.
9徐彤彤,王一锦,王晓珊.瘦素预处理对小鼠心肌冷缺血-再灌注损伤的保护作用研究[J].中国急救医学,2010,30(8):711-715. 被引量：9
10Scherer PE,Willams S,Fogliano M. Anovel serum protein similar to Clq,produced exclusively in adipocytes[J].Journal of Biological Chemistry,1995.26746-26749.

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二级参考文献45

1徐彤彤,阳跃忠.急性心肌梗死患者血清瘦素水平的变化及其临床意义[J].临床内科杂志,2007,24(2):106-108. 被引量：11
2徐彤彤,阳跃忠.大鼠急性心梗中血浆瘦素及血流动力学参数变化的探讨[J].中国临床药理学与治疗学,2007,12(2):191-194. 被引量：8
3徐彤彤,戴玲.瘦素与急性心肌梗死溶栓后ST段变化的关系探讨[J].广西医科大学学报,2007,24(3):403-405. 被引量：11
4Jahania MS, Sanchez JA, Narayan P, et al. Heart preservation for transplantation: principles and strategies[J]. Ann Thorac Surg, 1999,68(5):1983-1987.
5Zheng X, Lian D, Wong A, et al. Novel small interfering RNA-containing solution protecting donor organs in heart transplantation[J]. Circulation, 2009, 120(12):1099-1107.
6Zhang YY, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue[J]. Nature, 1994,372(6505):294-298.
7Collins S, Surwit RS. Pharmacologic manipulation of ob expression in a dietmodel of obesity[J]. J Biol Chem, 1996,271(16):9437-9440.
8Slieker LJ, Sloop KW, Surface PL, et al. Regulatione of expression of ob mRNA and protein by glucocorticoids and cAMP[J]. J Biol Chem, 1996,271(10): 5301-5304.
9Purdham DM, Zou MX, Rajapurohitam V, et al. Rat heart is a site of leptin production and action[J]. Am J Physiol Heart Circ Physiol, 2004,287(6):H2877-2884.
10Smith CC, Mocanu MM, Davidson SM, et al. Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects[J]. Br J Pharmacol, 2006,149(1):5-13.