全胚冷冻再行解冻胚胎移植周期的临床结局分析

Retrospective Analysis of Clinical Outcome in Frozen-thawed Embryo Transfer Cycles

目的:探讨新鲜移植周期与冻融胚胎移植(FET)周期妊娠结局的差异。方法:回顾性分析本中心刺激周期行新鲜胚移植(190例)和全部胚胎冷冻后再行FET(97例)周期的临床妊娠率、种植率以及流产率。结果:190例刺激周期新鲜胚胎种植后的妊娠率、种植率、流产率分别为47.4%(90/190)、30.2%(103/341)、10.0%(9/90),97例全部胚胎冷冻后行FET后的妊娠率、种植率、流产率分别为60.8%(59/97)、47.0%(86/183)、10.2%(6/59),组间妊娠率与种植率均有统计学差异(P<0.05),流产率无统计学差异(P>0.05)。结论:对于有OHSS风险等不适宜进行新鲜胚胎移植的患者,选择全部胚胎冷冻并择期进行FET,并不降低胚胎种植率和临床妊娠率,从而预防迟发型OHSS的发生,可获得更为理想的妊娠结局。

Objective： To compare clinical outcome of fresh embryo transfer（ET） cycles and frozenthawed embryo transfer（FET） cycles.Methods： A total of 287 cycles were analyzed retrospectively to compare the pregnancy rates,implantation rates and abortion rates between fresh ET（190 cases） and FET cycles（97 cases）.Results： The pregnancy rate,implantation rate and abortion rate were 47.4%（90/190）,30.2%（103/341） and 10.0%（9/90） in fresh ET cycles,comparing with 60.8%（59/97）,47.0%（86/183） and 10.2%（6/59） respectively,in FET cycles.The pregnancy rates and implantation rates were significantly different between fresh ET and FET cycles（P〈0.05）,the abortion rates were not significantly different（P〉0.05）.Conclusion： The fresh embryos were cryopreserved and then transferred in FET cycles in patients with some symptom and sign of ovarian hyperstimulation syndrome（OHSS）,and it did not reduce implantation rates and pregnancy rates.Modifying the transfer strategy will reduce the risk of OHSS later and gain a better clinical outcome.