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子宫内膜蜕膜化过程的调节机制 被引量：6

Regulatory Mechanism of Endometrial Decidualization
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摘要 子宫内膜蜕膜化是胚泡植入、胎盘形成以及妊娠维持的必备条件之一。蜕膜化时,子宫内膜间质细胞(endometrial stromal cells,ESCs)在形态和功能上都发生明显改变。生理情况下,ESCs主要受卵巢雌、孕激素的影响向蜕膜间质细胞转化;在体外实验中,多种细胞因子、激素、免疫细胞、转录因子等都参与调节ESCs模拟蜕膜化过程,有利于人们对蜕膜化机制的理解。 Decidualization of endometrial stromal cells（ESCs） is essential for successful blastocyst implantation,placenta formation and pregnancy maintenance.During decidualization,ESCs undergo large morphological and functional changes.Physically,ESCs are mainly decidualized by the influence of ovarian steroids;various of cytokines,hormones,leukocytes,transcription factor,etc.can induce decidualization in vitro,which is benefit for the research of decidualization mechanism.
作者 李辉 李明清 李大金
机构地区 复旦大学附属妇产科医院研究所生殖免疫研究室
出处 《生殖与避孕》 CAS CSCD 2012年第4期259-263,共5页 Reproduction and Contraception
基金 国家自然科学基金项目 项目编号:31101064 上海市卫生局科研项目 项目编号:2011Y081
关键词 子宫内膜间质细胞(ESCs) 蜕膜化 调节机制 endometrial stromal cells（ESCs） decidualization regulatory mechanism
分类号 R321 [医药卫生—人体解剖和组织胚胎学]
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参考文献24

  • 1Ramathal CY,Bagchi IC,Taylor RN,et al.Endometrialdecidualization:of mice and men.Semin Reprod Med,2010,28(1):17-26.
  • 2Maruyama T,Yoshimura Y.Molecular and cellular mecha-nisms for differentiation and regulation of the uterineendometrium.Endocr J,2008,55(5):795-810.
  • 3Salker M,Teklenburg G,Molokhia M,et al.Natural selectionof human embryos:impaired decidualization of endometriumdisables embryo-maternal interactions and causes recurrentpregnancy loss.PLoS One,2010,5(4):e10287.
  • 4Pakrasi PL,Jain AK.Cyclooxygenase-2 derived PGE2 andPGI2 play an important role via EP2 and PPARd receptorsin early steps of oil induced decidualization in mice.Placenta,2008,29(3):523-30.
  • 5Ganeff C,Chatel G,Munaut C,et al.The IGF system in in-vitro human decidualization.Mol Hum Reprod,2009,15(1):27-38.
  • 6Stoikos CJ,Harrison CA,Salamonsen LA,et al.A distinctcohort of the TGFβsuperfamily members expressed inhuman endometrium regulate decidualization.Hum Reprod,2008,23(6):1447-56.
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  • 8Kane NM,Jones M,Brosens JJ,et al.TGFbeta1attenuates expression of prolactin and IGFBP-1in decidualized en-dometrial stromal cells by both SMAD-dependent and SMAD-independent pathways.PLoS One,2010,5(9):e12970.
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同被引文献73

  • 1阳艳,章汉旺.EMX2、HOXA10与子宫内膜容受性[J].生殖与避孕,2006,26(2):95-98. 被引量：7
  • 2王和平,王常勇,江红.子宫内膜体外构建及其应用研究进展[J].生殖医学杂志,2007,16(1):60-63. 被引量：2
  • 3Kosmas IP, Kolibianakis EM, Devroey P. Association of estradiol levels on the day of hCG administration and pregnancyachie vement in IVF: a systematic review. Hum Reprod, 2004, 19(11):2446-53.
  • 4Papageorgiou T, Guibert J, Goffinet F, et al. Percentile curves of serum estradiol levels during controlled ovarian stimula- tion in 905 cycles stimulated with recombinant FSH show that high estradiol is not detrimental to IVF outcome. Hum Reprod, 2002, 17(11):2846-50.
  • 5Wu CH, Kuo TC, Wu HH, et al. High serum estradiol levels are not detrimental to in vitro fertilization outcome. Taiwan J Obstet Gynecol, 2007, 46(1):54-9.
  • 6Farhi J, Ben-Haroush A, Andrawus N, et al. High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation. Reprod Biomed Online, 2010, 21(3):331-7.
  • 7Carmona-Ruiz IO, Galache-Vega P, Santos-Haliscak R, et al. Influence of the high peak serum estradiol on the outcome of in vitro fertilization cycles. Ginecol Obstet Mex, 2010, 78 (10):553-8.
  • 8Valbuena D, Jasper M, Remohi J, et al. Ovarian stimulation and endometrial receptivity. Hum Reprod, 1999, 14(Suppl 2):107-11.
  • 9Makkar G, Ng EHY, Tang OS, et al. Reduced expression of Interleukin-11 and Intedeukin-6 in the periimplantation endometrium of excessive ovarian responders during in vitro fertilization treatment. Clin Endocrinol Metab, 2006, 91(8):3181-8.
  • 10Var T, Tonguc E, Dogan M, et al. Relationship between the oestradiol/oocyte ratio and the outcome of assisted repro- ductive technology cycles with gonadotropin releasing hor- mone agonist. Gynecol Endocrinol. 2011, 27(8):558-61.

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生殖与避孕
2012年 第4期

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