急性脑梗死后血浆肾上腺髓质素水平的动态变化及其意义

Dynamic change and its significance of the level of plasma adrenomedullin after acute cerebral infarction

目的观察急性脑梗死(ACI)后血浆肾上腺髓质素(AM)水平的动态变化及其意义。方法应用放射免疫法测定92例ACI患者和60名正常人的血浆AM含量,并进行比较。结果 ACI组发病后24h、48 h、7 d、21 d时AM浓度分别为(63.38±4.45)pg/ml、(90.13±6.59)pg/ml、(55.80±7.27)pg/ml和(37.68±6.70)pg/ml。ACI组各时间点血浆AM水平均显著高于正常对照组[(32.13±5.69)pg/ml](P<0.05～0.01)。ACI组血浆AM水平自发病后开始增高,至48 h达高峰,随后呈下降趋势。ACI组各时间点AM浓度之间比较差异有统计学意义(均P<0.01)。结论 ACI后血浆AM水平明显升高。AM系统参与了ACI的发病过程,起到一定的神经保护作用,并可能作为ACI早期诊断的标记物。

Objective To observe the dynamic change and its significance of the level of plasma adrenomedullin（AM） after acute cerebral infarction（ACI）.Methods Radioimmunoassay was applied to determine the plasma concentrations of AM in 92 ACI patients and 60 normal controls.The result was compared.Results The levels of plasm AM at 24 h,48 h,7 d and 21 d after ACI onset were（63.38±4.45）pg/ml,（90.13±6.59）pg/ml,（55.80±7.27）pg/ml and（37.68±6.70）pg/ml,respectively.The levels of plasm AM at each time point in ACI group were significantly higher than that in normal control group [（32.13±5.69） pg/ml]（P0.05-0.01）.The level of plasm AM in ACI group began to up-regulate since after onset and then reached peak at 48 h.Then it showed a downward trend.There were significantly differences among the levels of plasm AM at different time points in ACI group（all P0.01）.Conclusions The level of plasma AM is increased after ACI.AM system involved in the pathogenesis of ACI,and it plays an important role in the neuroprotective function.AM can be used as a marker for early diagnosis of ACI.