创伤性视神经损伤动物模型研究进展

Animal models of traumatic optic neuropathy: recent advance

创伤性视神经损伤(TON)是在外力作用下引起的视神经损伤,尚缺乏确切的治疗方法,预后较差,是颅脑外伤致残率较高的主要原因之一。随着神经生物学和分子生物学研究的进展,视神经损伤和再生的研究成为神经科学研究的热点和难点。本文针对各种创伤性视神经损伤动物模型的优缺点进行综述,为进一步建立理想的动物模型及进行前瞻性实验研究提供参考。

Traumatic optic neuropathy（TON） is caused by blunt trauma and has poor prognosis due to lack of effective treatments,and it is a main reason for high rate of disability after traumatic brain injury.Progression in neurobiology and molecular biology has made it a research focus to study optic nerve damage and regeneration.This article reviews the advantages and disadvantages of various animal TON models,paving a way for establishing ideal TON models and for future prospective researches.