癌相关CD8^+记忆T细胞在过继免疫治疗中的应用

Cancer-associated CD8^+ memory T cells in the application of adoptive immunotherapy

针对癌症患者的过继免疫治疗是临床肿瘤治疗研究中的热点话题。癌症患者体内天然存在着能够对恶性肿瘤细胞进行识别、攻击和杀伤的癌相关CD8+记忆T细胞,它们具有对少量肿瘤细胞产生快速免疫应答和持续长期发挥抗癌作用的优点。癌相关CD8+记忆T细胞主要存在于骨髓中,如将骨髓中的这部分T细胞分离出来,并以特定手段激活并回输体内,将可发挥强大的免疫治疗作用。为了帮助临床癌症治疗研究者们更加清晰地认识癌相关CD8+记忆T细胞的生物学特性、肿瘤杀伤能力和临床治疗效果,并妥善处理实际应用过程中遇到的各种问题,本文对近年有关癌相关CD8+记忆T细胞在肿瘤免疫治疗中应用的研究进展加以介绍。

In the research area of clinical cancer therapy, the adoptive immunotherapy has been a hot Iopic. There are natural anticancer CD8 ＋ memory T cells existing in the patient body, which can actively recognize, targe! and kill eaneer cells. These T eells respond rapidly to only a small number of cancer cells re-circulating in the body and act as a long-term cancer surveillance force there. Bone marrow is the major place where the anticancer CD8 ＋ memory T cells reside. If isolated, primed and expanded properly, bone marrow-derived anticancer CD8 ＋ memory T cells can exhibit a giant power in the adoptive immunotherapy. In order to give clinical researchers a clear picture of the biological characteristics and/hera- peutic values of anticancer CD8 ^＋ memory T cells as well as to help them deal with the problems encountered in the clinical application, we reviewed recent research progressions on the application of anticancer CD8 ＋ memol7 T ceils in the cancer imnmnotherapy