非霍奇金淋巴瘤发病风险与乙型肝炎病毒感染相关性的Meta分析

Association between infection of hepatitis B virus and onset risk of non-Hodgkin lymphoma:A Meta analysis

目的:采用Meta分析方法系统评价乙型肝炎病毒(hepatitis B virus,HBV)感染与非霍奇金淋巴瘤(non-Hodgkinlymphoma,NHL)发病风险的相关性。方法:计算机检索Medline、EMBASE、PubMed、Cochrane图书馆、中国生物医学文献数据库、中国期刊全文数据库、中国科技期刊全文数据库,收集有关HBV感染与NHL发病风险相关性的病例对照研究。两名评价者独立提取纳入研究的有效信息,并使用STATA 11.0进行Meta分析。结果:共纳入15篇病例对照研究及8篇巢式病例对照研究文献。Meta分析结果显示,固定效应模型下比值比(odd radio,OR)为2.44(95%CI,2.25～2.63),随机效应模型下OR为2.49(95%CI,1.95～3.18),然而,所有的纳入研究间存在异质性(I2=86.8%,P<0.05)。亚组分析中纳入的巢式病例对照研究之间无异质性(I2=15.9%,P>0.05),随机效应模型下OR为2.16(95%CI,1.82～2.56),提示NHL患者HBV的感染率高于对照人群。结论:HBV感染可能增加NHL的发病风险,但仍需大量的实验及流行病学研究验证。

Objective：To systematically evaluate the association between hepatitis B virus（HBV） infection and non-Hodgkin lymphoma（NHL）.Methods： Case-control studies on the association of HBV infection with NHL were collected from Medline,EMBASE,PubMed,the Cochrane Library,Chinese Biomedical Literature Database,Chinese Scientific Journal Full-text Database,and Chinese Journal Full-text Database.The data extraction and Meta-analysis（STATA 11.0） was performed by two reviewers independently.Results： 15 case-control studies and 8 nested case-control studies were included in the present study.The Meta results showed that odd radio（OR） of HBV infection in NHL when compared with the control population was 2.44（95% CI,2.25-2.63） in the fixed effect model and 2.49（95% CI,1.95-3.18） in the random effect model.There was evidence of statistical heterogeneity in all included studies（I2=86.8%,P0.05）,which disappeared in the subgroup nested case-control studies（I2=15.9%,P0.05）.OR was 2.49（95% CI,1.95-3.18） in the random effect model,suggesting a higher prevalence of HBV carrier state in NHL than controls.Conclusion： There is a possible causal relation between HBV infection and NHL,which needs to be confirmed by experimental and epidemiological studies.