微生物法合成生物高分子——聚羟基脂肪酸(酯)进展

Microbial Production of Natural Macromolecule Polymer-polyhydroxyalkanoates

生物高分子不但具有重要的生理作用,而且以其卓越的结构特性广泛应用于工业领域。微生物法合成生物高分子具有原料来源丰富、反应条件温和、易规模化生产等优点,正在逐渐成为生产天然高分子聚合物的重要方法。文中系统阐述了聚羟基脂肪酸(酯)天然高分子聚合物的微生物法合成途径、高产菌株筛选、发酵过程优化策略、产物提取及工业化生产前景和应用领域,以期为天然生物高分子聚合物的深入研究和广泛应用提供借鉴。

Natural macromolecule polymers are diverse,abundant,and important for life,exhibit fascinating structural properties and are of increasing importance for various applications in industrial fields.The technology for natural macromolecule polymers production by biosynthesis method is often characterized with abundant feedstock on a mild reaction condition and can be readily applied in industrial scale.Polyhydroxyalkanoates illustrated can be synthesized by microbiology directly.In this review,the current knowledge on the high-producing strains,biosynthesis pathway,the optimization strategies of the fermentation process,recovery,perspectives of this natural macromolecule polymers and applications are summarized.