摘要
以N-甲基-4-哌啶酮和8-氯-10,11-二氢-4-氮杂-5H-二苯并[a,d]-5-环庚酮为原料,经McMurry反应得到8-氯-6,11-二氢-11-(1-甲基-4-哌啶烯基)-5H-苯并[5,6]庚环[1,2-b]吡啶,收率为83.9%,最后与氯甲酸乙酯反应得到氯雷他定,总收率为35.7%。对McMurry反应过程中产生的副产物3、4进行了分离、表征。
The McMurry reaction of N-methyl-4-piperidone with 8-Chloro-10,11-dihydro-4-aza-5H-dibenzocyclohepten-5-one afforded 8-Chloro-6,11-dihydro-11-（1-methyl-pipridin-4-ylene）-5H-benzo-cyclohepta pyridine in 83.9% yield,and subsequently was treated with ethyl chlorocarbonate to give Loratadine in a overall yield of 35.7%.The by-products of 3 and 4 generated in McMurry reaction were separated and characterized.
出处
《化学通报》
CAS
CSCD
北大核心
2012年第4期353-356,共4页
Chemistry
