大剂量丙种球蛋白治疗小儿急性感染性多发神经根炎的疗效观察

High-dose gamma globulin in treatment of children acute multiple nerve root infectious inflammation

目的评价静脉注射大剂量人血丙种球蛋白(IVIG)治疗小儿急性感染性多发神经根炎的临床疗效。方法将小儿急性感染性多发神经根炎患者94例纳入研究,按入院先后顺序随机分为对照组和观察组,每组47例。在以复合维生素、加兰他敏、能量合剂等综合治疗的基础上,对照组采用地塞米松0.5～1.0mg/kg.d,连用5～8d,继以泼尼松龙维持;观察组采用IVIG400mg/kg.d,iv,连用5d。比较分析两组治疗后的疗效指标。结果观察组48h内总有效率86.7%,对照组21.4%;观察组肌力、行走恢复正常所需时间平均18.6天,对照组30.3天,组间比较差异具有显著性(P<0.05)。结论 IVIG治疗小儿急性感染性多发神经根炎的疗效显著,副作用低,优于地塞米松治疗,可在临床推广应用。

Objective To explore the clinical efficacy of high-dose intravenous gamma globulin（IVIG） in treatment of children acute multiple nerve root infectious inflammation.Methods 94 children with acute multiple nerve root infectious inflammation were included in the study.According to admission order,they were randomly divided into observation group and control group（n=47）.On the basis of comprehensive treatment in the use of vitamin,galantamine,energy mixture,etc.Control group was given dexamethasone 0.5~1.0mg/kg·d,continuous use 5 ~ 8d,followed by maintenance prednisolone.However,the observation group was given IVIG400mg/kg·d,iv,continuous use 5d.After treatment,a comparative analysis of the efficacy of indicators.Results The total efficiency in 48h is 86.7% in observation group,while was 21.4% in the control group;Observation group returned to normal muscle strength and walking time is the average 18.6 days,while the control group was 30.3 days.Difference was significant between groups（P0.05）.Conclusion IVIG in treatment of children acute multiple nerve root infectious inflammation effect is significant,side effects is low,better than the dexamethasone treatment,worthy of promotion.