超声造影对肝细胞癌与肝局灶性结节增生的定量对比分析

Quantification analysis of contrast enhanced ultrasonography on hepatocellular carcinoma and focal nodular hyperplasia

目的探讨超声造影(CEUS)对肝细胞癌(HCC)与肝局灶性结节增生(FNH)的声学定量对比价值。方法回顾性分析64例HCC和21例FNH患者,对其CEUS检查结果进行定量分析,从时间-强度曲线(TIC)上得到下列定量参数:达峰绝对值(DPI)、达峰时间(TTP)、曲线下面积(AUC)、曲线上升支斜率、下降支斜率的绝对值以及病灶与肝实质相应参数相比所得的标化值sDPI、sAUC,进行统计学分析。结果 HCC组的AUC、曲线上升支斜率、sDPI及sAUC分别均小于FNH组(P<0.05),而TTP、曲线下降支斜率的绝对值大于FNH组(P<0.05),两组的DPI无显著差异(P>0.05)。结论超声造影技术结合时间-强度曲线定量分析对HCC和FNH的鉴别诊断有重要的临床应用价值。

Objective To investigate the value of quantification analysis of contrast enhanced ultrasonography（CEUS）in differential diagnosis of hepatocellular carcinoma（HCC）and focal nodular hyperplasia（FNH）.Methods 64 HCCs and 21 FNHs were off-line analyzed with dynamic images.Quantitative parameters such as derived peak intensity（DPI）,time to peak（TTP）,area under the curve（AUC）, slop of rise,the absolute value for slop of down were acquired,and the standardized values（sDPI,sAUC） included the ratio of parameters from the focus to those from hepatic parenchyma.These quantitative parameters were analyzed by statistics.Results Quantitative parameters such as AUC,slop of rise,sDPI and sAUC in HCC group were smaller than those in FNH group（P〈0.05）,then TTP and the absolute value for slop of down were greater than those in FNH group（p0.05）.There was no significance of DPI between two groups（P〈0.05）.Conclusion TIC of contrast enhanced ultrasonography can provide quantitative analysis for HCC and FNH with preferable clinical application value.