不同来源供肾移植与术后环孢素A使用对患者术后肾功能的影响研究

Effects of different sources of donor kidney and cyclosporine A on renal function in patients after kidney transplantation

目的探讨不同来源供肾移植以及患者术后肾功能和环孢素A(CsA)用量范围。方法对该院收治的接受肾移植的患者根据供肾的来源分为活体组以及尸体组,对两组患者的疗效、并发症、术后肾脏功能以及CsA的血药浓度进行比较。结果活体组患者的疗效、肾脏功能以及肾脏存活率均优于尸体组,差异有统计学意义(P<0.05)。活体组患者CsA的利用率高于尸体组,差异有统计学意义(P<0.05)。结论活体供肾有助于降低热缺血以及冷缺血时间,提高CsA的利用度以及患者肾脏5年生存率,降低患者急性排斥的发生,改善患者预后。

Objective To investigate the influence of different sources of donor kidney and cyclosporine A（CsA） on renal function in patients after kidney transplantation.Methods Patients,receiving kidney transplantation,were divided into living group and corpse group according to the sources of donor,and compared for the therapeutic efficacy,complications,postoperative renal function and blood concentration of CsA.Results The therapeutic efficacy,kidney function,kidney survival rate and bioavailability of CsA in living group were better than corpse group（P0.05）.Conclusion Kidney transplantation of living donor might be helpful for decreasing warm ischemia and cold ischemia time,increasing bioavailability of CsA and five-year survival rate of transplanted kidney,reducing the incidence of acute rejection and improving prognosis.