血清胱抑素C在早期糖尿病肾病患者诊断中的应用

Application of serum cystatin C detection for the early diagnosis of diabetic nephropathy

目的讨论血清胱抑素C(CysC)、β2-微球蛋白(β2-MG)、超敏C反应蛋白(hs-CRP)和尿微量清蛋白(mAlb)在早期糖尿病肾病中的应用价值。方法采用免疫比浊法检测120例早期糖尿病肾病患者和55例健康者CysC、β2-MG、hs-CRP和mAlb,并对两组数据进行对比分析。结果早期糖尿病肾病组CysC、β2-MG、hs-CRP和mAlb均明显高于健康对照组,差异有统计学意义(P<0.05)。结论 CysC可与β2-MG、hs-CRP和mAlb联合检测从而提高早期糖尿病肾病患者的检出率。

Objective To discuss the application value of serum cystatin C（CysC） ,β2 microglobulin（β2-MG） ,high-sensitive C-reactive protein（hs-CRP） and urinary micro-albumin（mAlb） for the early diagnosis of diabetic nephropathy（DN） .Methods 120 cases of patients with early phase of DN and 55 cases of healthy subjects were enrolled and detected for CysC,β2-MG,hs-CRP and mAlb with immunoturbidimetry and data of the two groups were compared.Results Levels of CysC,β2-MG,hs-CRP and mAlb in patients group were higher than those in healthy group（P0.01 or P0.05） .Conclusion Combined detection of CysC,β2-MG,hs-CRP and mAlb could increase the diagnostic rate of patients with early DN.