不明原因复发性自然流产患者外周血淋巴细胞亚群特征的研究

Characteristics investigation of lymphocyte subgroups in peripheral blood of patients with unexplained recurrent spontaneous abortion

目的探讨不明原因复发性自然流产患者外周血免疫细胞亚群的特征。方法将34例早孕难免流产患者分为不明原因复发性自然流产(URSA)和偶发性自然流产(SA)两组,采用流式细胞术检测患者外周血免疫细胞的特征,将两组的检测结果进行比对研究。结果 Th/Ts两组均见异常升高,URSA组为(2.77±5.16),SA组为(3.67±6.12);NK细胞比例URSA组为(15.57±6.45)%明显升高,而SA组仅为(11.38±3.66)%,两组差异有统计学意义(P<0.05)。结论 URSA组与SA组均存在一定的免疫紊乱,共同的表现是特异性免疫方面均有Th/Ts异常升高,不同的表现是URSA组在非特异性免疫方面NK细胞比例增高较SA组更为明显。

Objective To investigate the characteristics of lymphocyte subgroups in peripheral blood of patients with unexplained recurrent spontaneous abortion（URSA） .Methods 34 cases of patients at early stage of pregnancy and with inevitable abortion were divided into tow groups,including URSA group and sporadic spontaneous abortion group（SA group） .Flow cytometry was performed to detect characteristics of lymphocyte subgroups in peripheral blood.Results of the two groups were compared.Results Increasing of helper T cells（Th） /suppressor T cells（Ts） could be demonstrated in both groups,with（2.77±5.16） in URSA group and（3.67±6.12） in SA group.Proportion of natural killer（NK） cells in URSA group and SA group was（15.57±6.45） % and（11.38±3.66） % respective,and with statistical difference between the two groups（P0.05） .Conclusion Patients with URSA and SA might be with certain degree of immunologic derangement,demonstrated as the increasing of Th/Ts.But according to nonspecific immunity,increasing of the proportion of NK cells might be more obvious in URSA group than that in SA group.