1327例宫颈病变患者液基薄层细胞学筛查结果分析

ThinPrep cytology test results analysis of 1327 cases of patients with cervical diseases

目的探讨液基薄层细胞学(TCT)检查在宫颈病变筛查中的应用价值。方法对1327例患者进行TCT检查,并将诊断为腺细胞异常(ASCUS)以上病变者进行阴道镜下组织多点活检后,做病理组织学检查。结果 1327例患者TCT检查阳性325例,其中ASCUS192例(59.1%),非典型鳞状上皮细胞(ASC-H)21例(6.5%),低度鳞状上皮内瘤病变(LSIL)56例(17.2%),高度鳞状上皮内瘤病变(HSIL)41例(12.6%),鳞癌(SCC)11例(3.4%),腺癌(AC)4例(1.2%);TCT与病理组织诊断符合率:LISL为83.9%,HSIL为92.6%,宫颈癌为100%。325例TCT结果异常者中31～40岁的患者有135例,占41.5%,其中LSIL和HSIL分别为51.8%和51.2%,CIN为34.2%,浸润癌为56.3%。结论 TCT诊断与病理组织学诊断有较高的符合率,TCT检查技术在宫颈病变筛查中具有重要的临床实用价值,是适合大面积普查宫颈病变的有效方法。

Objective To explore application value of ThinPrep cytology test（TCT） for the screening of cervical lesions.Methods 1 327 cases of patients were detected by TCT.Multiple punch biopsy was performed in patients with ASCUS or higher degree lesions by colposcope for histopathologic examination.Results Among all 1 327 cases of patients,325 cases were with positive results of TCT,including 192（59.1%） cases of ASCUS,21（6.5%） cases of ASC-H,56（17.2%） cases of LSIL,41（12.6%） cases of HSIL,11（3.4%） cases of SCC and 4（1.2%） cases of AC.The diagnose accordance rate between TCT and histopathologic examination was 83.9% for LISL,92.6% for HSIL and 100% for cervical cancer.Of the 325 cases with abnormal TCT results,135（41.5%） cases were 31-40 years old,and 51.8% of LSIL,51.2% of HSIL,34.2% of CIN and 56.3% of invasive cervical cancer were from this age group.Conclusion Liquid-based cytology diagnosis and histopathological diagnosis could be with high compliance rate.TCT might have important application value for the screening of cervical diseases,and might be an effective method for extensive screening of cervical lesions.