双黄解毒乳膏治疗血热内蕴型寻常型银屑病的临床疗效观察

The clinical observation of shuanghuangjiedu Cream on psoriasis vulgaris with blood-heat sydrome

目的观察双黄解毒乳膏治疗寻常型银屑病的临床疗效,并探索双黄解毒乳膏治疗寻常型银屑病(血热内蕴型)的最佳剂量。方法采用随机、双盲、对照的方法,将288例患者分为双黄解毒乳膏低剂量组、高剂量组、维A酸组,3组均口服复方青黛丸,分别用低剂量双黄解毒乳膏、高剂量双黄解毒乳膏、维A酸软膏外涂患处,治疗6w,观察银屑病面积严重程度指数(PASI)评分、红斑、鳞屑、浸润程度的改善情况,并观察安全性。结果临床综合疗效分析:双黄解毒乳膏低剂量组、高剂量组均优于对照组,3组治疗后较治疗前PASI评分均明显降低(P<0.05),低剂量组与高剂量组均优于对照组(P<0.05),3组均能改善红斑、鳞屑、浸润,低剂量组与高剂量组均优于对照组(P<0.05)。结论低剂量双黄解毒乳膏、高剂量双黄解毒乳膏均能有效改善血热内蕴型银屑病的皮损,疗效优于维A酸软膏,在改善皮损时间方面,双黄解毒乳膏高剂量组优于低剂量组。

Objective This paper is to observe the clinical effect and study the optimum dose on psoriasis vulgaris of blood-heat sydrome of shuanghuangjiedu cream（SHJDC）.Methods A randomized double-dummy controlled study.288 cases were divided into SHJDC low dose group,SHJDC high dose group and Preserve A acid group,and three groups all take Fufang Qingdai Pill.after 6 weeks treatment,observe the improvement of PASI（Psoriasis Area and Sereverity Index）,erythema,scales and infiltration as well as ceam-safety.Results SHJDC low dose group and high dose group better than controlled group on PAS Ierythema,scales and infiltration（P0.05）.Conclusion The low and high dose group of SHJD cream both can improve the lesion of psoriasis with blood-heat sydrome,and effect better than Preserve A acid,while the high dose group of SHJDC better than low group on the disease course.