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EBP1在新疆哈萨克族食管鳞癌中的表达及临床病理学意义

Expression and clinical significance of EBP1 in esophageal cancer of the Kazak
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摘要 目的探讨新疆哈萨克族食管鳞癌中EBP1mRNA的表达情况及其与临床病理学特征的关系。方法利用RT-PCR技术检测37例哈萨克族食管鳞癌组织及其对应的癌旁正常食管上皮组织中EBP1mRNA的表达情况。结果 EBP1mRNA在新疆哈萨克族食管鳞癌组织和正常组织中的阳性表达率分别为67.6%(25/37)和89.2%(33/37),差异有统计学意义(P<0.05);EBP1mRNA的表达与TNM分期及淋巴结转移相关(P<0.05)。结论 EBP1mRNA表达缺失参与了哈萨克族食管鳞癌的发生及发展。 Objective To investigate the expression of EBP1 mRNA in esophageal squamous cell carcinoma（ESCC） in Kazak populations in Xinjiang and its relationship with clinicopathological characteristics.Methods The expressions of EBP1 mRNA in 37 cases of ESCC tissues and 37 cases of corresponding normal esophageal tissues were detected by reverse transcription polymerase chain reaction（RT-PCR）.Results The expression rates of EBP1 mRNA in ESCC tissues and normal tissues in Kazak were 67.6%（25/37） and 89.2%（33/37） respectively（P0.05）.There was a significant correlation between the expression of EBP1 mRNA and the TNM staging lymphatic metastasis（P0.05）.Conclusion The loss-expression of EBP1 mRNA was related to the pathogenesis and development of ESCC.
作者 范志勤 魏智勇 李卉 庞作良 李惠武 王洪江
机构地区 新疆医科大学附属肿瘤医院胸外科 新疆医科大学基础医学院
出处 《新疆医科大学学报》 CAS 2012年第4期436-438,共3页 Journal of Xinjiang Medical University
基金 国家自然科学基金项目(81160271)
关键词 食管鳞状细胞癌 EBP1 RT-PCR esophageal squamous cell carcinoma EBP1 reverse transcription polymerase chain reaction（RT-PCR）
分类号 R730.2 [医药卫生—肿瘤]
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参考文献10

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二级参考文献17

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新疆医科大学学报
2012年 第4期

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