盐酸利托君用于晚期先兆流产保胎治疗的疗效观察

Clinical observation of Ritodrine Hydrochloride in the treatment of fetus protection with late threatened abortion

目的探讨晚期先兆流产患者采用盐酸利托君保胎治疗的疗效。方法选取2008年6月～2010年6月我院收治的晚期先兆流产患者70例,按随机数字表法不同分为观察组和对照组,每组35例。对照组给予25%硫酸镁30 mL+5%葡萄糖溶液500 mL静脉滴注,观察组给予盐酸利托君50 mg+5%葡萄糖溶液500 mL静脉滴注。比较两组症状消失时间、宫缩消失时间、保胎成功率和不良反应发生率。结果观察组症状消失时间和宫缩消失时间均显著短于对照组(P<0.05),观察组保胎成功率[94.3%(33/35)]显著高于对照组[88.6%(31/35)](P<0.05),观察组不良反应发生率[25.7%(9/35)]与对照组[11.4%(4/35)]比较差异无统计学意义(P>0.05)。结论相比硫酸镁,盐酸利托君用于晚期先兆流产保胎治疗的疗效确切,起效时间更短,且不明显增加不良反应,显示出一定的优势。

Objective To investigate efficacy of Ritodrine Hydrochloride in the treatment of fetus protection with late threatened abortion. Methods A total of 70 patients with late threatened abortion in our hospital from June 2008 to June 2010 were selected and randomly divided into the observation group and the control group, with 35 cases in each group. The control group was given 25% Magnesium sulfate 30 mL and 5% Glucose solution 500 mL by intravenous drip, the observation group was given Ritodrine Hydrochloride 50 mg and 5% Glucose solution 500 mL by intravenous drip. The symptoms disappearance time, uterine contraction disappearance time, fetus protection success rate and incidence of adverse reactions of the two groups were compared. Results The symptoms disappear time and uterine contraction disappear time of observation group were significantly shorter than that of control group （P 〈 0.05）, and fetus protection success rate of the observation group [94.3% （33/35）] was significantly higher than the control group [88.6% （31/35）] （P 〈 0.05）. The incidence of adverse reactions of observation group [25.7% （9/35）] showed no significant difference with the control group [11.4% （4/35）] （P 〉 0.05）. Conclusion Compared with magnesium sulfate, the efficacy of Ritodrine Hydrochloride in the treatment of fetus protection with late threatened abortion, the onset time is shorter, and without significant increase in adverse reactions, showing a certain advantages.