伴绒毛膜上皮癌分化的子宫内膜未分化癌1例临床病理分析

Clinicopathological analysis of 1 case of endometrioid undifferentiated carcinoma with choriocacinomatous differentiation

通过对1例伴绒毛膜上皮癌分化的子宫内膜未分化癌进行临床、病理及免疫组化观察,结果发现,肿物大小约3.0 cm×2.5 cm,实性,质较硬,镜下肿瘤组织由分化差的上皮样细胞构成,癌细胞核大、异型,实性分布,间质少,可见多核合体细胞,核分裂多见。免疫组化显示瘤细胞CK7(+)、ER(-)、PR(-)、CD68(-),合体细胞HCG(+)。这是一种罕见的恶性肿瘤,一般预后较差,由于文献报道例数有限,预后的评价尚待进一步统计分析。

One case of endometrioid undifferentiated carcinoma with choriocacinomatous differentiation was observed clinically and pathologically with HE staining and immunohistochemistry.The results showed that,the endometrial neoplasia was about 3.0 cm×2.5 cm.The low-differentiated tumor cells were arranged in solid nets with scant stroma,marked atypically,multinucleated syncytial cells and convoluted nuclei.The tumor cells stained positively for CK7（＋）,syncytial cells negatively for ER（-）,PR（-）,CD68（-） positively for HCG（＋）.Endometrioid undifferentiated carcinoma with choriocacinomatous differentiation is a rare entity with features of higher malignant tumor,and the prognosis is difficult to be evaluated for rare cases reported.