IL-1β在胃癌患者血清中的表达及意义

The expression and clinical significance of IL-1β in patients with gastric cancer

目的探讨胃癌患者血清中白介素-1β(IL-1β)的表达及其临床意义。方法采用酶联免疫吸附实验法(ELISA)分别测定60例胃癌患者、慢性胃炎患者(60例)及健康体检者(60例)的血清IL-1β水平,并进行比较分析。结果胃癌组血清IL-1β水平明显高于慢性胃炎组和对照组,差异有统计学意义(P<0.05),而慢性胃炎组血清IL-1β水平和对照组血清中IL-1β水平比较差异无统计学意义(P>0.05);术后胃癌组患者血清IL-1β水平较术前明显下降(P<0.05),但仍高于对照组(P<0.05)。结论IL-1β在胃癌患者的血清中呈高表达状态,有望成为胃癌发生的预测指标。

Objective To explore the expression and clinical significance of serum IL-1β in gastric cancer patients.Methods The level of serum IL-1β was detected by ELISA and analyzed in 60 gastric cancer patients,60 chronic gastritis patients and 60 healthy people.Results The level of serum IL-1β in gastric cancer group was significantly higher than that in chronic gastritis patients and healthy controls（P 0.05）.While the difference between chronic gastritis patients and healthy controls was not statistically significant（P 0.05）.The level of serum IL-1β in gastric cancer patients reduced significantly compared with that before operation（P 0.05）,but was still higher than that in healthy controls.Conclusion Serum IL-1β is highly expressed in gastric cancer patients,so it is expected to become a prediction indicator of gastric cancer.