摘要
随着纳米技术及纳米材料的不断发展和完善,纳米粒子因其独特的结构和理化性质使其在一些疑难疾病的治疗上取得了明显进展。但纳米粒子作为异物进入机体,会引起一系列机体反应,影响固有免疫细胞的活性,促进免疫系统免疫分子的分泌,而且纳米粒子对抗原递呈细胞具有活化作用,可促进其对抗原的递呈,还可诱导激活抗原特异性CD8+T细胞免疫应答,从而介导抗原特异性细胞毒效应。此外,纳米粒子可增强体液免疫应答,并导致严重的炎症反应。
Nanoparticles have widely been used in medical field with development of nanotechnology and nanomaterials.Due to their unique chemical and physical properties,nanoparticles may provide new solutions to the diagnoses and therapies of some intractable diseases.But at the same time,nanoparticles as foreign bodies can induce a series of reactions.Nanoparticles can affect activity of natural immune cells and promote the secretion of natural immune molecules.In addition,nanoparticles can activate antigen presenting cells and enhance their ability of presenting the antigens.Nanoparticles were found to be a stronger inducer of antigen-specific CD8＋ T-cell response.They can induce antigen-specific cytotoxic effect.In addition,nanoparicles can enhance humoral immunity response,and induce serious inflammatory reaction.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2012年第2期242-246,126,共5页
Chinese Journal of Pharmacology and Toxicology
基金
国家重点基础研究计划资助项目(2010CB933904)~~
关键词
纳米粒子
免疫系统
细胞免疫
体液免疫
炎症反应
nanoparticles
immune system
cellular immunity
humoral immunity
inflammatory reaction
