厄贝沙坦治疗原发性高血压的临床疗效和靶器官保护

Target organ protective efficacy of irbesartan in essential hypertension

目的评价厄贝沙坦治疗原发性高血压的临床疗效及其对原发性高血压左心室肥厚(LVH)的逆转作用以及对肾功能的保护作用。方法 100例确诊为高血压病患者服用厄贝沙坦150 mg,每天1次,每周随访1次,治疗12周,监测治疗前及治疗中24 h动态血压水平及肾功能指标。用超声心动图测量LVH患者左心室肥厚的改善情况。结果厄贝沙坦治疗后,患者24 h平均收缩压及舒张压、日间及夜间收缩压及舒张压均有明显下降(P<0.01),血及尿β2-MG明显减少(P<0.01)。经厄贝沙坦治疗后左心室重量(left ventricular hypertraphy,LVMI)明显下降(P<0.01)。结论厄贝沙坦对原发性高血压患者有良好的平稳降压效果,对原发性高血压患者的LVH有逆转作用,且对其肾功能有良好的保护作用。

Objective To evaluate the efficacy of irbesartan in patients with essential hypertension on left ventricular hypertrophy（LVH） and renal function.MethodsOne Hundred patients diagnosed as essential hypertension were given irbesartan 150 mg,once a day for 12 weeks.The follow-up observation performed every week.The value of blood pressure,renal function indicators and situation of LVH were observed at pretherapy and during therapy.ResultsThe value of average systolic and diastolic blood pressure,including daytime and nighttime,as well as the value of blood and urine β2-MG and LVMI were all significantly decreased after irbesartan treatment（P〈0.01）.ConclusionIrbesartan is a valuable antihypertensive drug for essential hypertension patients which has effect of reducing blood pressure steady and protective effect on heart and renal.