左乙拉西坦治疗小儿癫痫疗效的Meta分析

The prognosis with levetiracetam treatment in children epilepsy:A systematic review

目的评价左乙拉西坦治疗小儿癫痫的疗效和安全性。方法计算机检索近十年(2001-2011)来PubMed、Cochrane Database of Systematic Reviews、EMbase、中国知网(CNKI)检索平台、万方数据库中纳入左乙拉西坦治疗小儿癫痫的随机对照研究(RCTs),研究者对文献质量进行严格评价和资料提取。对符合质量标准的RCTs用Review manager 5.0软件进行Meta分析。结果 6个RCTs共610名患者纳入研究,其中治疗组(使用左乙拉西坦)333例,对照组(常规治疗)277例。Meta分析结果表明治疗组患者每周癫痫发病率明显低于对照组,对于患者继发嗜睡、头痛等中枢系统不良反应及肝肾功能损害方面,RCTs结果显示无显著差异。结论左乙拉西坦治疗不良反应种类少,对各种发作类型的小儿癫痫均有良好疗效,且不增加发生其他不良结局的危险性,可作为小儿癫痫患者的首选治疗方案之一。

Objective To evaluate the efficacy and safety of levetiracetam Treatment in Children Epilepsy.Methods PubMed（2001-Sept.2011）,Cochrane Database of Systematic Reviews（2001-Sept.2011）,EMbase（2001-Sept.2011）,CNKI（2001-Sept.2011）,and Wanfang Database were searched without language limilation,correlated randomized controlled clinical trials（RCTs） evaluating the effectiveness and safety of levetiracetam Treatment in Children Epilepsy were searched.The researchers were strict quality evaluation and literature information extraction.The Cochrane Collaboration＇S RevMan5.0 software was used for the analysis of the data extracted from the included randomized controlled trials.Results Six randomized controlled trials involving 610 patients were included with all trials published in English,among which 333 cases were performed levetiracetam as the treatment group,277 cases were performed routine treatment as comparison group.Meta analysis results show that the treatment group was much lower than the weekly epilepsy patients in the control group.For nervous system symptom such as ssecondary sleepiness,headache and liver and kidney function,the RCTs results show that the damage was no significant differences.Conclusion It seemed that levetiracetam was effective for a wide range of epileptic seizures in children with epilepsy because of few kind of side effects occurred during the treatment.It was not increase the risk of the others adverse outcomes,and can be used in clinical treatment as one of the first therapies.